Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19

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Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19

Hopkins, Francis R. (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten

Govender, Melissa, 1989- (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten

Svanberg, Cecilia (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten

Nordgren, Johan, 1980- (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten

Waller, Hjalmar (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Precisionsmedicinskt laboratorium

Nilsdotter-Augustinsson, Åsa, 1962- (author): Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland

Henningsson, Anna J., 1972- (author): Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Division of Clinical Microbiology, Department of Laboratory Medicine in Jönköping, Ryhov County Hospital, Jönköping

Hagbom, Marie, 1971- (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten

Sjöwall, Johanna, 1977- (author): Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland

Nyström, Sofia N., 1971- (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin

Larsson, Marie, 1966- (author): Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten

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2023-01-04
2023
English.
In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 13

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://urn.kb.se/re...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Introduction: After more than two years the Coronavirus disease-19 (COVID-19) pandemic continues to burden healthcare systems and economies worldwide, and it is evident that the effects on the immune system can persist for months post-infection. The activity of myeloid cells such as monocytes and dendritic cells (DC) is essential for correct mobilization of the innate and adaptive responses to a pathogen. Impaired levels and responses of monocytes and DC to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is likely to be a driving force behind the immune dysregulation that characterizes severe COVID-19.Methods: Here, we followed a cohort of COVID-19 patients hospitalized during the early waves of the pandemic for 6-7 months. The levels and phenotypes of circulating monocyte and DC subsets were assessed to determine both the early and long-term effects of the SARS-CoV-2 infection.Results: We found increased monocyte levels that persisted for 6-7 months, mostly attributed to elevated levels of classical monocytes. Myeloid derived suppressor cells were also elevated over this period. While most DC subsets recovered from an initial decrease, we found elevated levels of cDC2/cDC3 at the 6-7 month timepoint. Analysis of functional markers on monocytes and DC revealed sustained reduction in program death ligand 1 (PD-L1) expression but increased CD86 expression across almost all cell types examined. Finally, C-reactive protein (CRP) correlated positively to the levels of intermediate monocytes and negatively to the recovery of DC subsets.Conclusion: By exploring the myeloid compartments, we show here that alterations in the immune landscape remain more than 6 months after severe COVID-19, which could be indicative of ongoing healing and/or persistence of viral antigens.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

COVID-19; SARS-CoV-2; dendritic cells; monocytes; myeloid compartment

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