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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004415naa a2200589 4500
001oai:gup.ub.gu.se/297893
003SwePub
008240910s2020 | |||||||||||000 ||eng|
009oai:research.chalmers.se:6b6cb8bc-5ee0-44e9-8943-da30e8d3bf95
024a https://gup.ub.gu.se/publication/2978932 URI
024a https://doi.org/10.1146/annurev-anchem-091619-1035122 DOI
024a https://research.chalmers.se/publication/5175882 URI
040 a (SwePub)gud (SwePub)cth
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Sämfors, Sanna,d 1987u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg4 aut0 (Swepub:gu)xfletj
2451 0a Lipid Diversity in Cells and Tissue Using Imaging SIMS
264 1b Annual Reviews,c 2020
520 a Lipids are an important class of biomolecules with many roles within cells and tissue. As targets for study, they present several challenges. They are difficult to label, as many labels lack the specificity to the many different lipid species or the labels maybe larger than the lipids themselves, thus severely perturbing the natural chemical environment. Mass spectrometry provides exceptional specificity and is often used to examine lipid extracts from different samples. However, spatial information is lost during extraction. Of the different imaging mass spectrometry methods available, secondary ion mass spectrometry (SIMS) is unique in its ability to analyze very small features, with probe sizes <50 nm available. It also offers high surface sensitivity and 3D imaging capability on a subcellular scale. This article reviews the current capabilities and some remaining challenges associated with imaging the diverse lipids present in cell and tissue samples. We show how the technique has moved beyond show-and-tell, proof-of-principle analysis and is now being used to address real biological challenges. These include imaging the microenvironment of cancer tumors, probing the pathophysiology of traumatic brain injury, or tracking the lipid composition through bacterial membranes. © 2020 by Annual Reviews. All rights reserved.
650 7a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Andra medicinska och farmaceutiska grundvetenskaper0 (SwePub)301992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Other Basic Medicine0 (SwePub)301992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Annan medicinsk bioteknologi0 (SwePub)304992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Other Medical Biotechnology0 (SwePub)304992 hsv//eng
653 a cells
653 a imaging
653 a lipids
653 a secondary ion mass spectrometry
653 a SIMS
653 a tissue
653 a Brain
653 a Molecular biology
653 a Bacterial membranes
653 a Chemical environment
653 a Current capability
653 a Imaging mass spectrometry
653 a Proof of principles
653 a Spatial informations
653 a Surface sensitivity
653 a Traumatic Brain Injuries
653 a tissue
700a Fletcher, John S.u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg4 aut0 (Swepub:cth)fletcher
710a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org
773t Annual Review of Analytical Chemistryd : Annual Reviewsg 13:1, s. 249-271q 13:1<249-271x 1936-1327x 1936-1335
8564 8u https://gup.ub.gu.se/publication/297893
8564 8u https://doi.org/10.1146/annurev-anchem-091619-103512
8564 8u https://research.chalmers.se/publication/517588

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