Sökning: WFRF:(Sämfors Sanna) > Lipid Diversity in ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04415naa a2200589 4500 | |
001 | oai:gup.ub.gu.se/297893 | |
003 | SwePub | |
008 | 240910s2020 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:6b6cb8bc-5ee0-44e9-8943-da30e8d3bf95 | |
024 | 7 | a https://gup.ub.gu.se/publication/2978932 URI |
024 | 7 | a https://doi.org/10.1146/annurev-anchem-091619-1035122 DOI |
024 | 7 | a https://research.chalmers.se/publication/5175882 URI |
040 | a (SwePub)gud (SwePub)cth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sämfors, Sanna,d 1987u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg4 aut0 (Swepub:gu)xfletj |
245 | 1 0 | a Lipid Diversity in Cells and Tissue Using Imaging SIMS |
264 | 1 | b Annual Reviews,c 2020 |
520 | a Lipids are an important class of biomolecules with many roles within cells and tissue. As targets for study, they present several challenges. They are difficult to label, as many labels lack the specificity to the many different lipid species or the labels maybe larger than the lipids themselves, thus severely perturbing the natural chemical environment. Mass spectrometry provides exceptional specificity and is often used to examine lipid extracts from different samples. However, spatial information is lost during extraction. Of the different imaging mass spectrometry methods available, secondary ion mass spectrometry (SIMS) is unique in its ability to analyze very small features, with probe sizes <50 nm available. It also offers high surface sensitivity and 3D imaging capability on a subcellular scale. This article reviews the current capabilities and some remaining challenges associated with imaging the diverse lipids present in cell and tissue samples. We show how the technique has moved beyond show-and-tell, proof-of-principle analysis and is now being used to address real biological challenges. These include imaging the microenvironment of cancer tumors, probing the pathophysiology of traumatic brain injury, or tracking the lipid composition through bacterial membranes. © 2020 by Annual Reviews. All rights reserved. | |
650 | 7 | a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Andra medicinska och farmaceutiska grundvetenskaper0 (SwePub)301992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Other Basic Medicine0 (SwePub)301992 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Annan medicinsk bioteknologi0 (SwePub)304992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Other Medical Biotechnology0 (SwePub)304992 hsv//eng |
653 | a cells | |
653 | a imaging | |
653 | a lipids | |
653 | a secondary ion mass spectrometry | |
653 | a SIMS | |
653 | a tissue | |
653 | a Brain | |
653 | a Molecular biology | |
653 | a Bacterial membranes | |
653 | a Chemical environment | |
653 | a Current capability | |
653 | a Imaging mass spectrometry | |
653 | a Proof of principles | |
653 | a Spatial informations | |
653 | a Surface sensitivity | |
653 | a Traumatic Brain Injuries | |
653 | a tissue | |
700 | 1 | a Fletcher, John S.u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg4 aut0 (Swepub:cth)fletcher |
710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
773 | 0 | t Annual Review of Analytical Chemistryd : Annual Reviewsg 13:1, s. 249-271q 13:1<249-271x 1936-1327x 1936-1335 |
856 | 4 8 | u https://gup.ub.gu.se/publication/297893 |
856 | 4 8 | u https://doi.org/10.1146/annurev-anchem-091619-103512 |
856 | 4 8 | u https://research.chalmers.se/publication/517588 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy