Sökning: WFRF:(Tivesten Anna) >
Growth hormone-indu...
Growth hormone-induced blood pressure decrease is associated with increased mRNA levels of the vascular smooth muscle KATP channel.
-
- Tivesten, Åsa, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
- Barlind, Anna, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
- Caidahl, Kenneth, 1949 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
-
visa fler...
-
- Klintland, Natalia, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
-
Cittadini, Antonio (författare)
-
- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
-
- Isgaard, Jörgen, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
visa färre...
-
(creator_code:org_t)
- Bioscientifica, 2004
- 2004
- Engelska.
-
Ingår i: The Journal of endocrinology. - : Bioscientifica. - 0022-0795 .- 1479-6805. ; 183:1, s. 195-202
- Relaterad länk:
-
https://joe.bioscien...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Growth hormone (GH) deficiency is associated with abnormal vascular reactivity and development of atherosclerosis. GH treatment in GH deficient states restores systemic vascular resistance, arterial compliance, endothelium-dependent and endothelium-independent vasodilation, and may reverse markers of early atherosclerosis. However, very little is known about the molecular mechanisms underlying these effects. In the present study, male Sprague Dawley rats were hypophysectomized and treated for two weeks with GH (recombinant human GH, 2 mg/kg/day) or saline as s.c. injections twice daily. GH decreased aortic systolic blood pressure compared with saline-treated animals, while the diastolic blood pressure was not significantly changed. GH treatment increased cardiac output as determined by Doppler-echocardiography and the calculated systemic vascular resistance was markedly reduced. In order to identify GH-regulated genes of importance for vascular function, aortic mRNA levels were analyzed by the microarray technique and correlated to the systolic blood pressure levels. Using this approach, we identified 18 GH-regulated genes with possible impact on vascular tone and atherogenesis. In particular, mRNA levels of the inwardly rectifying potassium channel Kir6.1 and the sulfonylurea receptor 2B, which together form the vascular smooth muscle ATP-sensitive potassium channel, were both up-regulated by GH treatment and highly correlated to systolic blood pressure. Our findings establish a major role for GH in the regulation of vascular physiology and gene expression. Increased expression of the ATP-sensitive potassium channel, recently shown to be crucial in the regulation of vascular tone, constitutes a possible mechanism by which GH governs vascular tone.
Nyckelord
- ATP-Binding Cassette Transporters
- genetics
- Animals
- Aorta
- Blood Pressure
- drug effects
- Cardiac Output
- drug effects
- Gene Expression
- drug effects
- Human Growth Hormone
- pharmacology
- Hypophysectomy
- Male
- Microarray Analysis
- Muscle
- Smooth
- Vascular
- metabolism
- Na(+)-K(+)-Exchanging ATPase
- genetics
- metabolism
- Potassium Channels
- genetics
- Potassium Channels
- Inwardly Rectifying
- genetics
- RNA
- Messenger
- analysis
- Rats
- Rats
- Sprague-Dawley
- Receptors
- Drug
- genetics
- Recombinant Proteins
- pharmacology
- Systole
- Vascular Resistance
- drug effects
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tivesten, Åsa, 1 ...
-
Barlind, Anna, 1 ...
-
Caidahl, Kenneth ...
-
Klintland, Natal ...
-
Cittadini, Anton ...
-
Ohlsson, Claes, ...
-
visa fler...
-
Isgaard, Jörgen, ...
-
visa färre...
- Artiklar i publikationen
-
The Journal of e ...
- Av lärosätet
-
Göteborgs universitet
-
Karolinska Institutet