Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSG-127

• A new class of very potent and selective non-nucleoside inhibitors of HIV reverse transcriptase (RT) has recently been identified, The prototype compound trovirdine (LY 300046 HCl) and one analogue, MSG-127, have been studied with respect to inhibition of

Nyckelord

human immunodeficiency virus (HIV) reverse transcriptase; mutant; enzyme kinetics; inhibitor; travirdine; STEADY-STATE KINETICS; NONNUCLEOSIDE INHIBITORS; PYRIDINONE DERIVATIVES; HIV-1 REPLICATION; ANTIVIRAL THERAPY; TEMPLATE; TETRAHYDROIMIDAZO<4;5;1-JK><

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