L773:1745 6673
Sökning: L773:1745 6673 > Urinary 2,5-hexaned...
- Persson, BodilLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden (författare)
Urinary 2,5-hexanedione excretion in cryptogenic polyneuropathy compared to the general Swedish population
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
- 2013-07-30
- BioMed Central,2013
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-96984
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96984URI
- https://doi.org/10.1186/1745-6673-8-21DOI
- https://lup.lub.lu.se/record/4042879URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206582URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Funding Agencies|Swedish Council for Work Life and Social Research||Medical Research Council of Southeast Sweden (FORSS)||
- Background2,5-hexanedione (2,5-HD) is the main neurotoxic metabolite of methyl-n-butyl ketone (MBK) and n-hexane, and known to cause polyneuropathy. The aim of our study was to compare the urinary levels of 2,5-HD between cases with cryptogenic polyneuropathy and the general Swedish population, and to elucidate the role of certain external factors.MethodsMorning urine samples were collected from 114 cases with cryptogenic polyneuropathy (77 men and 37 women) and 227 referents (110 men and 117 women) randomly selected from the population registry. None had any current occupational exposure to n-hexane or MBK. The urine samples were analysed by a gas chromatographic method based on acidic hydrolysis.ResultsCases had statistically higher urinary levels of 2,5-HD (0.48 mg/L) than the general population (0.41 mg/L) and men higher excretion than women (0.48 mg/L and 0.38 mg/L, respectively). There was no difference in 2,5-HD levels between current smokers and non-smokers. Occupational exposure to xylene, alcohol consumption and ever exposed to general anaesthesia were associated with lower excretion in men while for occupational exposure to nitrous oxide in women higher excretion was seen. Higher excretion of 2,5 HD was inversely related to increasing age.ConclusionsSignificantly higher levels of urinary 2,5-HD were seen in men and cryptogenic polyneuropathy cases seemingly unexposed to n-hexane. Hypothetically, this might be due to either differences in metabolic patterns or some concealed exposure. The difference in means between cases and the general population is small and can therefore not allow any firm conclusions of the causality, however.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
- Polyneuropathy
- Cryptogenic
- Urine
- 2
- 5-hexanedione
- General population
- Sweden
- Occupational exposure
- MEDICINE
- MEDICIN
- Occupational exposure
- Sweden
- General population
- 5-hexanedione
- 2
- Urine
- Polyneuropathy
- Cryptogenic
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Vrethem, MagnusÖstergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken(Swepub:liu)magvr07 (författare)
- Murgia, NicolaUniversity of Perugia, Italy (författare)
- Lindh, JonasRyhov County Hospital, Sweden (författare)
- Hällsten, Anna-LenaÖstergötlands Läns Landsting,Linköpings universitet,Yrkes- och miljömedicin,Hälsouniversitetet,Arbets- och miljömedicin(Swepub:liu)annha03 (författare)
- Fredrikson, MatsLinköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet(Swepub:liu)matfr43 (författare)
- Tondel, MartinUppsala universitet,Arbets- och miljömedicin,Uppsala University, Sweden(Swepub:uu)marto779 (författare)
- Avdelningen för arbets- och miljömedicinInstitutionen för laboratoriemedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Occupational Medicine and Toxicology: BioMed Central81745-6673
Internetlänk
- https://doi.org/10.1186/1745-6673-8-21Fulltext
- https://liu.diva-portal.org/smash/get/diva2:644948/FULLTEXT01.pdffulltext:print
- https://occup-med.biomedcentral.com/track/pdf/10.1186/1745-6673-8-21
- https://portal.research.lu.se/files/3680776/4281425.pdfFULLTEXT
- http://dx.doi.org/10.1186/1745-6673-8-21FULLTEXT
- https://uu.diva-portal.org/smash/get/diva2:644816/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96984
- https://doi.org/10.1186/1745-6673-8-21
- https://lup.lub.lu.se/record/4042879
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206582
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- Tondel, Martin
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