WFRF:(Ambikan Anoop T.)
Sökning: WFRF:(Ambikan Anoop T.) > Genome-scale metabo...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03223naa a2200433 4500 | |
| 001 | oai:DiVA.org:su-205219 | |
| 003 | SwePub | |
| 008 | 220603s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:149656215 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2052192 URI |
| 024 | 7 | a https://doi.org/10.26508/lsa.2022014052 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1496562152 URI |
| 040 | a (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ambikan, Anoop T.u Karolinska Institutet4 aut |
| 245 | 1 0 | a Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection |
| 264 | c 2022-05-10 | |
| 264 | 1 | b Life Science Alliance, LLC,c 2022 |
| 338 | a print2 rdacarrier | |
| 520 | a Genome-scale metabolic models (GSMMs) can provide novel insights into metabolic reprogramming during disease progression and therapeutic interventions. We developed a context-specific system-level GSMM of people living with HIV (PLWH) using global RNA sequencing data from PBMCs with suppressive viremia either by natural (elite controllers, PLWHEC) or drug-induced (PLWHART) control. This GSMM was compared with HIV-negative controls (HC) to provide a comprehensive systems-level metabo-transcriptomic characterization. Transcriptomic analysis identified up-regulation of oxidative phosphorylation as a characteristic of PLWHART, differentiating them from PLWHEC with dysregulated complexes I, III, and IV. The flux balance analysis identified altered flux in several intermediates of glycolysis including pyruvate, a-ketoglutarate, and glutamate, among others, in PLWHART. The in vitro pharmacological inhibition of OXPHOS complexes in a latent lymphocytic cell model (J-Lat 10.6) suggested a role for complex IV in latency reversal and immunosenescence. Furthermore, inhibition of complexes I/III/IV induced apoptosis, collectively indicating their contribution to reservoir dynamics. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 700 | 1 | a Svensson-Akusjärvi, Sarau Karolinska Institutet4 aut |
| 700 | 1 | a Krishnan, Shuba4 aut |
| 700 | 1 | a Sperk, Maikeu Karolinska Institutet4 aut |
| 700 | 1 | a Nowak, Piotru Karolinska Institutet4 aut |
| 700 | 1 | a Vesterbacka, Janu Karolinska Institutet4 aut |
| 700 | 1 | a Sönnerborg, Andersu Karolinska Institutet4 aut |
| 700 | 1 | a Benfeitas, Ruiu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)rube5211 |
| 700 | 1 | a Neogi, Ujjwalu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för biokemi och biofysik4 org |
| 773 | 0 | t Life Science Allianced : Life Science Alliance, LLCg 5:9q 5:9x 2575-1077 |
| 856 | 4 | u https://doi.org/10.26508/lsa.202201405y Fulltext |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-205219 |
| 856 | 4 8 | u https://doi.org/10.26508/lsa.202201405 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149656215 |
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