WFRF:(Aresh Bejan)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02468nam a2200313 4500 | |
| 001 | oai:DiVA.org:uu-284068 | |
| 003 | SwePub | |
| 008 | 160414| | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2840682 URI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a ovr2 swepub-publicationtype |
| 100 | 1 | a Aresh, Bejan,d 1984-u Uppsala universitet,Genetisk utvecklingsbiologi,Sensory Circuits4 aut0 (Swepub:uu)baiar311 |
| 245 | 1 0 | a Characterization of preproenkephalin expressing neurons in the nervous system using a transgenic line |
| 338 | a print2 rdacarrier | |
| 520 | a Here we have constructed a Cre line to target preproenkephalin expressing cells (Penk-Cre) using a BAC cloning strategy. By crossing our Penk-Cre line with the tdTomato reporter, tdTomato;Penk-Cre expressing cells could be visualized. Penk-Cre was expressed throughout the dorsal spinal cord, where approximately 50% of the neurons were residing within lamina III. Furthermore, single-cell analysis of spinal Penk-Cre expressing cells showed that 41% was positive for Penk mRNA and that a majority (94%) of the population expressed Vglut2 mRNA. Immunohistochemical analysis showed that only 7% and 13% expressed the inhibitory markers Viaat-egfp and Pax2, respectively, hence identifying spinal Penk-Cre expressing neurons as mainly excitatory. The expression of Penk-Cre in the brain was extensive, including dense expression in the striatum, nucleus accumbens and several amygdaloid nuclei. Furthermore, Penk-Cre expression was also shown in insular cortex, cingulated cortex, primary and secondary somatosensory cortices and the trigeminal nuclei. The Penk-Cre line represents a useful genetic tool for future analysis of PENK expressing neurons in the nervous system. | |
| 653 | a characterization | |
| 653 | a Cre | |
| 653 | a preproenkephalin | |
| 653 | a Penk | |
| 653 | a Medicinsk vetenskap | |
| 653 | a Medical Science | |
| 700 | 1 | a Moelijker, Nynkeu Uppsala universitet,Genetisk utvecklingsbiologi,Sensory Circuits4 aut |
| 700 | 1 | a Blümel, Eddau Uppsala universitet,Genetisk utvecklingsbiologi,Sensory Circuits4 aut |
| 700 | 1 | a Lagerström, Malinu Uppsala universitet,Genetisk utvecklingsbiologi,Sensory Circuits4 aut |
| 710 | 2 | a Uppsala universitetb Genetisk utvecklingsbiologi4 org |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-284068 |
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- Moelijker, Nynke
- Blümel, Edda
- Lagerström, Mali ...
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- Uppsala universitet
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