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Early interactions ...
Early interactions between leukocytes and three different potentially bioactive titanium surface modifications
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- Arvidsson, Anna, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg
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- Malmberg, Per, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg
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- Kjellin, Per, 1972 (författare)
- Promimic AB
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- Currie, Fredrik (författare)
- Promimic AB
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- Arvidsson, Martin, 1973 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Franke Stenport, Victoria, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg
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(creator_code:org_t)
- 2011-03-25
- 2011
- Engelska.
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Ingår i: Journal of Biomedical Materials Research. Part B - Applied biomaterials. - : Wiley. - 1552-4973 .- 1552-4981. ; 97:2, s. 364-72
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- The aim of the present study was to compare the early interactions between leukocytes and three different surface modifications, suggested as bioactive. Blasted titanium discs were modified by alkali and heat treatment, sodium fluoride treatment, or hydroxyapatite coating. A number of these discs were also immersed in simulated body fluid (SBF) for a week, a treatment which yielded high levels of calcium and phosphate on each surface type. The specimens were exposed for human venous blood for 32 minutes and the respiratory burst response was measured in terms of reactive oxygen species with a luminometer, and coverage of viable cells with a fluorescence microscope after staining steps. The topography, morphology, and chemistry of the surfaces were evaluated with optical interferometry and scanning electron microscopy/energy dispersive X-ray analysis (SEM/EDX). A high respiratory burst response was found for HA coated titanium in comparison with the other surface groups (p < 0.0005). The SBF immersion resulted in an increased respiratory burst response (p < 0.0005) and removed statistically significant differences between the surface groups. Thus, the results in the present study indicate that different titanium surface modifications influence the early inflammatory response differently, and that calcium phosphate compounds increase the inflammatory response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Body Fluids
- chemistry
- Coated Materials
- Biocompatible
- chemistry
- metabolism
- Durapatite
- chemistry
- Hot Temperature
- Humans
- Leukocytes
- immunology
- Materials Testing
- Reactive Oxygen Species
- metabolism
- Respiratory Burst
- physiology
- Sodium Fluoride
- chemistry
- Surface Properties
- Titanium
- chemistry
- metabolism
- Reactive Oxygen Species
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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