Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC)

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Fältnamn	Indikatorer	Metadata
000		04719naa a2200757 4500
001		oai:gup.ub.gu.se/335693
003		SwePub
008		240528s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3356932 URI
024	7	a https://doi.org/10.1245/s10434-021-11236-y2 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a van Akkooi, Alexander C. J.4 aut
245	1 0	a Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC)
264		c 2022-01-28
264	1	b Springer Science and Business Media LLC,c 2022
520		a Exciting advances in melanoma systemic therapies have presented the opportunity for surgical oncologists and their multidisciplinary colleagues to test the neoadjuvant systemic treatment approach in high-risk, resectable metastatic melanomas. Here we describe the state of the science of neoadjuvant systemic therapy (NAST) for melanoma, focusing on the surgical aspects and the key role of the surgical oncologist in this treatment paradigm. This paper summarizes the past decade of developments in melanoma treatment and the current evidence for NAST in stage III melanoma specifically. Issues of surgical relevance are discussed, including the risk of progression on NAST prior to surgery. Technical aspects, such as the definition of resectability for melanoma and the extent and scope of routine surgery are presented. Other important issues, such as the utility of radiographic response evaluation and method of pathologic response evaluation, are addressed. Surgical complications and perioperative management of NAST related adverse events are considered. The International Neoadjuvant Melanoma Consortium has the goal of harmonizing NAST trials in melanoma to facilitate rapid advances with new approaches, and facilitating the comparison of results across trials evaluating different treatment regimens. Our ultimate goals are to provide definitive proof of the safety and efficacy of NAST in melanoma, sufficient for NAST to become an acceptable standard of care, and to leverage this platform to allow more personalized, biomarker-driven, tailored approaches to subsequent treatment and surveillance.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Hieken, Tina J.4 aut
700	1	a Burton, Elizabeth M.4 aut
700	1	a Ariyan, Charlotte4 aut
700	1	a Ascierto, Paolo A.4 aut
700	1	a Asero, Salvatore V. M. A.4 aut
700	1	a Blank, Christian U.4 aut
700	1	a Block, Matthew S.4 aut
700	1	a Boland, Genevieve M.4 aut
700	1	a Caraco, Corrado4 aut
700	1	a Chng, Sydney4 aut
700	1	a Davidson, B. Scott4 aut
700	1	a Duprat Neto, Joao Pedreira4 aut
700	1	a Faries, Mark B.4 aut
700	1	a Gershenwald, Jeffrey E.4 aut
700	1	a Grunhagen, Dirk J.4 aut
700	1	a Gyorki, David E.4 aut
700	1	a Han, Dale4 aut
700	1	a Hayes, Andrew J.4 aut
700	1	a van Houdt, Winan J.4 aut
700	1	a Karakousis, George C.4 aut
700	1	a Klop, Willem M. C.4 aut
700	1	a Long, Georgina4 aut
700	1	a Lowe, Michael C.4 aut
700	1	a Menzies, Alexander M.4 aut
700	1	a Olofsson Bagge, Roger,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xoloro
700	1	a Pennington, Thomas E.4 aut
700	1	a Rutkowski, Piotr4 aut
700	1	a Saw, Robyn P. M.4 aut
700	1	a Scolyer, Richard A.4 aut
700	1	a Shannon, Kerwin F.4 aut
700	1	a Sondak, Vernon K.4 aut
700	1	a Tawbi, Hussein4 aut
700	1	a Testori, Alessandro A. E.4 aut
700	1	a Tetzlaff, Mike T.4 aut
700	1	a Thompson, John F.4 aut
700	1	a Zager, Jonathan S.4 aut
700	1	a Zuur, Charlotte L.4 aut
700	1	a Wargo, Jennifer A.4 aut
700	1	a Spillane, Andrew J.4 aut
700	1	a Ross, Merrick4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för kirurgi4 org
773	0	t ANNALS OF SURGICAL ONCOLOGYd : Springer Science and Business Media LLCg 29:6, s. 3694-3708q 29:6<3694-3708x 1068-9265x 1534-4681
856	4 8	u https://gup.ub.gu.se/publication/335693
856	4 8	u https://doi.org/10.1245/s10434-021-11236-y

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Av författaren/redakt...: van Akkooi, Alex ...; Hieken, Tina J.; Burton, Elizabet ...; Ariyan, Charlott ...; Ascierto, Paolo ...; Asero, Salvatore ...; visa fler...; Blank, Christian ...; Block, Matthew S ...; Boland, Geneviev ...; Caraco, Corrado; Chng, Sydney; Davidson, B. Sco ...; Duprat Neto, Joa ...; Faries, Mark B.; Gershenwald, Jef ...; Grunhagen, Dirk ...; Gyorki, David E.; Han, Dale; Hayes, Andrew J.; van Houdt, Winan ...; Karakousis, Geor ...; Klop, Willem M. ...; Long, Georgina; Lowe, Michael C.; Menzies, Alexand ...; Olofsson Bagge, ...; Pennington, Thom ...; Rutkowski, Piotr; Saw, Robyn P. M.; Scolyer, Richard ...; Shannon, Kerwin ...; Sondak, Vernon K ...; Tawbi, Hussein; Testori, Alessan ...; Tetzlaff, Mike T ...; Thompson, John F ...; Zager, Jonathan ...; Zuur, Charlotte ...; Wargo, Jennifer ...; Spillane, Andrew ...; Ross, Merrick; visa färre...

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