WFRF:(Baecher G.)
Sökning: WFRF:(Baecher G.) > Outcomes with adjuv...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05292naa a2200925 4500 | |
| 001 | oai:gup.ub.gu.se/318577 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3185772 URI |
| 024 | 7 | a https://doi.org/10.1136/jitc-2021-0044172 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Eroglu, Z.4 aut |
| 245 | 1 0 | a Outcomes with adjuvant anti-PD-1 therapy in patients with sentinel lymph node-positive melanoma without completion lymph node dissection |
| 264 | c 2022-08-24 | |
| 264 | 1 | b BMJ,c 2022 |
| 520 | a Until recently, most patients with sentinel lymph node-positive (SLN+) melanoma underwent a completion lymph node dissection (CLND), as mandated in published trials of adjuvant systemic therapies. Following multicenter selective lymphadenectomy trial-II, most patients with SLN+ melanoma no longer undergo a CLND prior to adjuvant systemic therapy. A retrospective analysis of clinical outcomes in SLN+ melanoma patients treated with adjuvant systemic therapy after July 2017 was performed in 21 international cancer centers. Of 462 patients who received systemic adjuvant therapy, 326 patients received adjuvant anti-PD-1 without prior immediate (IM) CLND, while 60 underwent IM CLND. With median follow-up of 21 months, 24-month relapse-free survival (RFS) was 67% (95% CI 62% to 73%) in the 326 patients. When the patient subgroups who would have been eligible for the two adjuvant anti-PD-1 clinical trials mandating IM CLND were analyzed separately, 24-month RFS rates were 64%, very similar to the RFS rates from those studies. Of these no-CLND patients, those with SLN tumor deposit >1 mm, stage IIIC/D and ulcerated primary had worse RFS. Of the patients who relapsed on adjuvant anti-PD-1, those without IM CLND had a higher rate of relapse in the regional nodal basin than those with IM CLND (46% vs 11%). Therefore, 55% of patients who relapsed without prior CLND underwent surgery including therapeutic lymph node dissection (TLND), with 30% relapsing a second time; there was no difference in subsequent relapse between patients who received observation vs secondary adjuvant therapy. Despite the increased frequency of nodal relapses, adjuvant anti-PD-1 therapy may be as effective in SLN+ pts who forego IM CLND and salvage surgery with TLND at relapse may be a viable option for these patients. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Melanoma | |
| 653 | a Adjuvants | |
| 653 | a Immunologic | |
| 653 | a stage-iii | |
| 653 | a ipilimumab | |
| 653 | a nivolumab | |
| 653 | a Oncology | |
| 653 | a Immunology | |
| 700 | 1 | a Broman, K. K.4 aut |
| 700 | 1 | a Thompson, J. F.4 aut |
| 700 | 1 | a Nijhuis, A.4 aut |
| 700 | 1 | a Hieken, T. J.4 aut |
| 700 | 1 | a Kottschade, L.4 aut |
| 700 | 1 | a Farma, J. M.4 aut |
| 700 | 1 | a Hotz, M.4 aut |
| 700 | 1 | a Deneve, J.4 aut |
| 700 | 1 | a Fleming, M.4 aut |
| 700 | 1 | a Bartlett, E. K.4 aut |
| 700 | 1 | a Sharma, A.4 aut |
| 700 | 1 | a Dossett, L.4 aut |
| 700 | 1 | a Hughes, T.4 aut |
| 700 | 1 | a Gyorki, D. E.4 aut |
| 700 | 1 | a Downs, J.4 aut |
| 700 | 1 | a Karakousis, G.4 aut |
| 700 | 1 | a Song, Y.4 aut |
| 700 | 1 | a Lee, A.4 aut |
| 700 | 1 | a Berman, R. S.4 aut |
| 700 | 1 | a van Akkooi, A.4 aut |
| 700 | 1 | a Stahlie, E.4 aut |
| 700 | 1 | a Han, D. L.4 aut |
| 700 | 1 | a Vetto, J.4 aut |
| 700 | 1 | a Beasley, G.4 aut |
| 700 | 1 | a Farrow, N. E.4 aut |
| 700 | 1 | a Hui, J. Y. C.4 aut |
| 700 | 1 | a Moncrieff, M.4 aut |
| 700 | 1 | a Nobes, J.4 aut |
| 700 | 1 | a Baecher, K.4 aut |
| 700 | 1 | a Perez, M.4 aut |
| 700 | 1 | a Lowe, M.4 aut |
| 700 | 1 | a Ollila, D. W.4 aut |
| 700 | 1 | a Collichio, F. A.4 aut |
| 700 | 1 | a Olofsson Bagge, Roger,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Sahlgrenska Centrum för Cancerforskning (SCCR),Institute of Clinical Sciences, Department of Surgery,Sahlgrenska Center for Cancer Research (SCCR)4 aut0 (Swepub:gu)xoloro |
| 700 | 1 | a Mattsson, Janu Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Sahlgrenska Center for Cancer Research (SCCR),Institute of Clinical Sciences, Department of Surgery4 aut |
| 700 | 1 | a Kroon, H. M.4 aut |
| 700 | 1 | a Chai, H.4 aut |
| 700 | 1 | a Teras, J.4 aut |
| 700 | 1 | a Sun, J.4 aut |
| 700 | 1 | a Carr, M. J.4 aut |
| 700 | 1 | a Tandon, A.4 aut |
| 700 | 1 | a Babacan, N. A.4 aut |
| 700 | 1 | a Kim, Y.4 aut |
| 700 | 1 | a Naqvi, M.4 aut |
| 700 | 1 | a Zager, J.4 aut |
| 700 | 1 | a Khushalani, N. I.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för kirurgi4 org |
| 773 | 0 | t Journal for Immunotherapy of Cancerd : BMJg 10:8q 10:8x 2051-1426 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/318577 |
| 856 | 4 8 | u https://doi.org/10.1136/jitc-2021-004417 |
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- Eroglu, Z.
- Broman, K. K.
- Thompson, J. F.
- Nijhuis, A.
- Hieken, T. J.
- Kottschade, L.
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- Farma, J. M.
- Hotz, M.
- Deneve, J.
- Fleming, M.
- Bartlett, E. K.
- Sharma, A.
- Dossett, L.
- Hughes, T.
- Gyorki, D. E.
- Downs, J.
- Karakousis, G.
- Song, Y.
- Lee, A.
- Berman, R. S.
- van Akkooi, A.
- Stahlie, E.
- Han, D. L.
- Vetto, J.
- Beasley, G.
- Farrow, N. E.
- Hui, J. Y. C.
- Moncrieff, M.
- Nobes, J.
- Baecher, K.
- Perez, M.
- Lowe, M.
- Ollila, D. W.
- Collichio, F. A.
- Olofsson Bagge, ...
- Mattsson, Jan
- Kroon, H. M.
- Chai, H.
- Teras, J.
- Sun, J.
- Carr, M. J.
- Tandon, A.
- Babacan, N. A.
- Kim, Y.
- Naqvi, M.
- Zager, J.
- Khushalani, N. I ...
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