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Repetitive use of l...
Repetitive use of levosimendan in advanced heart failure : need for stronger evidence in a field in dire need of a useful therapy
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- Poelzl, Gerhard (author)
- Univ Klin Innsbruck, Innsbruck, Austria.
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- Altenberger, Johann (author)
- Rehabil Zentrum Grossgmain, Salzburg, Austria.
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- Baholli, Loant (author)
- Klinikum Dortmund Mitte, Dortmund, Germany.
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- Beltran, Paola (author)
- HM Broggi, Barcelona, Spain.
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- Borbely, Attila (author)
- Univ Debrecen, Fac Med, Div Clin Physiol, Debrecen, Hungary.
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- Comin-Colet, Josep (author)
- Univ Hosp Bellvitge, Barcelona, Spain.
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- Delgado, Juan F. (author)
- Hosp 12 Octubre, Madrid, Spain.
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- Fedele, Francesco (author)
- Sapienza Univ, Policlin Umberto 1, Rome, Italy.
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- Fontana, Antonella (author)
- Orion Pharma Srl, Milan, Italy.
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- Fruhwald, Friedrich (author)
- Med Univ Klin, Graz, Austria.
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- Giamouzis, Gregory (author)
- Univ Thessaly, Larissa Univ Hosp, Larisa, Greece.
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- Giannakoulas, George (author)
- Aristotle Univ Thessaloniki, Thessaloniki, Greece.
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- Garcia-Gonzalez, Martin J. (author)
- H La Laguna, Tenerife, Spain.
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- Gustafsson, Finn (author)
- Rigshosp, Copenhagen, Denmark.
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- Kaikkonen, Kari (author)
- Oulu Univ Hosp, Oulu, Finland.
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- Kivikko, Matti (author)
- Orion Pharma, Espoo, Finland.
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- Kubica, Jacek (author)
- Nicolaus Copernicus Univ, Coll Med, Bydgoszcz, Poland.
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- von Lewinski, Dirk (author)
- Med Univ Klin, Graz, Austria.
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- Lofman, Ida (author)
- Karolinska Institutet
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- Malfatto, Gabriella (author)
- Ist Auxol Italiano, Milan, Italy.
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- Manito, Nicolas (author)
- Univ Hosp Bellvitge, Barcelona, Spain.
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- Martinez-Selles, Martin (author)
- H Gregorio Maranon, Madrid, Spain.
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- Masip, Josep (author)
- HM Broggi, Barcelona, Spain.
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- Merkely, Bela (author)
- Semmelweis Univ, Heart & Vasc Ctr, Budapest, Hungary.
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- Morandi, Fabrizio (author)
- Circolo Hosp & Macchi Fdn, Varese, Italy.
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- Molgaard, Henning (author)
- Aarhus Univ Hosp, Skejby, Denmark.
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- Oliva, Fabrizio (author)
- Osped Niguarda Ca Granda, Milan, Italy.
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- Pantev, Emil (author)
- Helsingborgs Iasarett, Helsingborg, Sweden.
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- Papp, Zoltan (author)
- Univ Debrecen, Fac Med, Div Clin Physiol, Debrecen, Hungary.
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- Perna, Gian Piero (author)
- Osped Riuniti, Dipartimento Sci Cardiol Med Chirurg, Ancona, Italy.
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- Pfister, Roman (author)
- Univ Cologne, Herzzentrum, Klin Innere Med 3, Cologne, Germany.
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- Piazza, Vito (author)
- Azienda Osped San Camillo Forlanini, Rome, Italy.
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- Bover, Ramon (author)
- H Clin San Carlos, Madrid, Spain.
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- Rangel-Sousa, Diego (author)
- H Virgen Rocio, Seville, Spain.
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- Recio-Mayoral, Alejandro (author)
- Hosp Univ Virgen Macarena, Seville, Spain.
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- Reinecke, Alexander (author)
- Uni Klinikum Schleswig Holstein, Kiel, Germany.
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- Rieth, Andreas (author)
- Kerckhoff Klin, Bad Nauheim, Germany.
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- Sarapohja, Toni (author)
- Orion Pharma, Espoo, Finland.
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- Schmidt, Gunter (author)
- CHARITE Univ Med Berlin, Berlin, Germany.
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- Seidel, Mirko (author)
- Unfallkrankenhaus Berlin, Innere Med Klin, Berlin, Germany.
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- Stoerk, Stefan (author)
- Univ Wurzburg, Comprehens Heart Failure Ctr, Wurzburg, Germany.;Univ Hosp, Wurzburg, Germany.
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- Vrtovec, Bojan (author)
- Univ Clin Ctr, Ljubljana, Slovenia.
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- Wikström, Gerhard (author)
- Uppsala universitet,Kardiologi
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- Yerly, Patrik (author)
- CHU Vaudois, Lausanne, Switzerland.
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- Pollesello, Piero (author)
- Orion Pharma, Espoo, Finland.
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Univ Klin Innsbruck, Innsbruck, Austria Rehabil Zentrum Grossgmain, Salzburg, Austria. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 243, s. 389-395
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://www.internati...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Patients in the latest stages of heart failure are severely compromised, with poor quality of life and frequent hospitalizations. Heart transplantation and left ventricular assist device implantation are viable options only for a minority, and intermittent or continuous infusions of positive inotropes may be needed as a bridge therapy or as a symptomatic approach. In these settings, levosimendan has potential advantages over conventional inotropes (catecholamines and phosphodiesterase inhibitors), such as sustained effects after initial infusion, synergy with beta-blockers, and no increase in oxygen consumption. Levosimendan has been suggested as a treatment that reduces re-hospitalization and improves quality of life. However, previous clinical studies of intermittent infusions of levosimendan were not powered to show statistical significance on key outcome parameters. A panel of 45 expert clinicians from 12 European countries met in Rome on November 24-25, 2016 to review the literature and envision an appropriately designed clinical trial addressing these needs. In the earlier FIGHT trial (daily subcutaneous injection of liraglutide in heart failure patients with reduced ejection fraction) a composite Global Rank Score was used as primary end-point where death, re-hospitalization, and change in N-terminalprohormone-brain natriuretic peptide level were considered in a hierarchical order. In the present study, we tested the same end-point post hoc in the PERSIST and LEVOREP trials on oral and repeated i.v. levosimendan, respectively, and demonstrated superiority of levosimendan treatment vs placebo. The use of the same composite end-point in a properly powered study on repetitive levosimendan in advanced heart failure is strongly advocated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Advanced heart failure
- Levosimendan
- Intermittent
- Repetitive
- Clinical trial
- Composite end-point
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Poelzl, Gerhard
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Altenberger, Joh ...
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Baholli, Loant
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Beltran, Paola
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Borbely, Attila
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Comin-Colet, Jos ...
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show more...
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Delgado, Juan F.
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Fedele, Francesc ...
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Fontana, Antonel ...
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Fruhwald, Friedr ...
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Giamouzis, Grego ...
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Giannakoulas, Ge ...
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Garcia-Gonzalez, ...
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Gustafsson, Finn
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Kaikkonen, Kari
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Kivikko, Matti
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Kubica, Jacek
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von Lewinski, Di ...
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Lofman, Ida
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Malfatto, Gabrie ...
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Manito, Nicolas
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Martinez-Selles, ...
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Masip, Josep
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Merkely, Bela
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Morandi, Fabrizi ...
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Molgaard, Hennin ...
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Oliva, Fabrizio
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Pantev, Emil
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Papp, Zoltan
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Perna, Gian Pier ...
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Pfister, Roman
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Piazza, Vito
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Bover, Ramon
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Rangel-Sousa, Di ...
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Recio-Mayoral, A ...
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Reinecke, Alexan ...
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Rieth, Andreas
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Sarapohja, Toni
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Schmidt, Gunter
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Seidel, Mirko
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Stoerk, Stefan
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Vrtovec, Bojan
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Wikström, Gerhar ...
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Yerly, Patrik
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Pollesello, Pier ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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International Jo ...
- By the university
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Uppsala University
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Karolinska Institutet