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Sökning: WFRF:(Bala P) > (2006-2009) > Chromosome 22 array...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003319naa a2200433 4500
001oai:DiVA.org:uu-10562
003SwePub
008070510s2006 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105622 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Benetkiewicz, Magdalenau Uppsala universitet,Institutionen för genetik och patologi4 aut
2451 0a Chromosome 22 array-CGH profiling of breast cancer delimited minimal common regions of genomic imbalances and revealed frequent intra-tumoral genetic heterogeneity
264 1c 2006
338 a print2 rdacarrier
520 a Breast cancer is a common malignancy and the second most frequent cause of death among women. Our aim was to perform DNA copy number profiling of 22q in breast tumors using a methodology which is superior, as compared to the ones applied previously. We studied 83 biopsies from 63 tumors obtained from 60 female patients. A general conclusion is that multiple distinct patterns of genetic aberrations were observed, which included deletion(s) and/or gain(s), ranging in size from affecting the whole chromosome to only a few hundred kb. Overall, the analysis revealed genomic imbalances of 22q in 22% (14 out of 63) of tumors. The predominant profile (11%) was monosomy 22. The smallest identified candidate region, in the vicinity of telomere of 22q, encompasses approximately 220 kb and was involved in all but one of the tumors with aberrations on chromosome 22. This segment is dense in genes and contains 11 confirmed and one predicted gene. The availability of multiple biopsies from a single tumor provides an excellent opportunity for analysis of possible intra-tumor differences in genetic profiles. In 15 tumors we had access to two or three biopsies derived from the same lesion and these were studied independently. Four out of 15 (26.6%) tumors displayed indications of clonal intra-tumor genotypic differences, which should be viewed as a high number, considering that we studied in detail only a single human chromosome. Our results open up several avenues for continued genetic research of breast cancer.
653 a genomic array
653 a 22q
653 a telomere
653 a clonal intra-tumor genotypic differences
653 a complex aberrations
653 a biopsies
653 a MEDICINE
653 a MEDICIN
7001 a Piotrowski, Arkadiuszu Uppsala universitet,Institutionen för genetik och patologi4 aut
7001 a Díaz de Ståhl, Teresitau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)testahl
7001 a Jankowski, Michal4 aut
7001 a Bala, Dariusz4 aut
7001 a Hoffman, Jacek4 aut
7001 a Srutek, Ewa4 aut
7001 a Laskowski, Ryszard4 aut
7001 a Zegarski, Wojciech4 aut
7001 a Dumanski, Jan P.u Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)janduman
7102 a Uppsala universitetb Institutionen för genetik och patologi4 org
7730 t International Journal of Oncologyg 29:4, s. 935-945q 29:4<935-945x 1019-6439x 1791-2423
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-10562

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