Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry

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Fältnamn	Indikatorer	Metadata
000		04594naa a2200433 4500
001		oai:DiVA.org:uu-441715
003		SwePub
008		210504s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4417152 URI
024	7	a https://doi.org/10.1016/j.ijpara.2020.09.0062 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Emery-Corbin, Samantha J.u Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia; Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia4 aut
245	1 0	a Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry
264	1	b Elsevier,c 2021
338		a print2 rdacarrier
520		a Diarrheal disease caused by Giardia duodenalis is highly prevalent, causing over 200 million cases globally each year. The processes that drive parasite virulence, host immune evasion and transmission involve coordinated gene expression and have been linked to epigenetic regulation. Epigenetic regulatory systems are eukaryote-conserved, including in deep branching excavates such as Giardia, with several studies already implicating histone post-translational modifications in regulation of its pathogenesis and life cycle. However, further insights into Giardia chromatin dynamics have been hindered by a lack of site-specific knowledge of histone modifications. Using mass spectrometry, we have provided the first known molecular map of histone methylation, acetylation and phosphorylation modifications in Giardia core histones. We have identified over 50 previously unreported histone modifications including sites with established roles in epigenetic regulation, and co-occurring modifications indicative of post-translational modification crosstalk. These demonstrate conserved histone modifications in Giardia which are equivalent to many other eukaryotes, and suggest that similar epigenetic mechanisms are in place in this parasite. Further, we used sequence, domain and structural homology to annotate putative histone enzyme networks in Giardia, highlighting representative chromatin modifiers which appear sufficient for identified sites, particularly those from H3 and H4 variants. This study is to our knowledge the first and most comprehensive, complete and accurate view of Giardia histone post-translational modifications to date, and a substantial step towards understanding their associations in parasite development and virulence.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653		a Giardia
653		a Histone
653		a Chromatin
653		a Phosphorylation
653		a Methylation
653		a Acetylation
700	1	a Hamey, Joshua J.u Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW, Australia4 aut
700	1	a Balan, Baluu Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia; Univ Melbourne, Melbourne Vet Sch, Fac Vet & Agr Sci, Dept Vet Biosci, Parkville, Vic, Australia; Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia4 aut
700	1	a Rojas-López, Laurau Uppsala universitet,Mikrobiologi4 aut0 (Swepub:uu)lauro675
700	1	a Svärd, Staffan G.u Uppsala universitet,Mikrobiologi4 aut0 (Swepub:uu)stsva021
700	1	a Jex, Aaron R.u Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia; Univ Melbourne, Melbourne Vet Sch, Fac Vet & Agr Sci, Dept Vet Biosci, Parkville, Vic, Australia; Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia4 aut
710	2	a Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia; Univ Melbourne, Dept Med Biol, Parkville, Vic, Australiab Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW, Australia4 org
773	0	t International Journal of Parasitologyd : Elsevierg 51:4, s. 225-239q 51:4<225-239x 0020-7519x 1879-0135
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441715
856	4 8	u https://doi.org/10.1016/j.ijpara.2020.09.006

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Av författaren/redakt...: Emery-Corbin, Sa ...; Hamey, Joshua J.; Balan, Balu; Rojas-López, Lau ...; Svärd, Staffan G ...; Jex, Aaron R.

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