WFRF:(Bartoschek Michael)
Sökning: WFRF:(Bartoschek Michael) > PDGF family functio...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03399naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:72b5a96a-b3e6-4e7f-a308-b38a6544c71b | |
| 003 | SwePub | |
| 008 | 180704s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/72b5a96a-b3e6-4e7f-a308-b38a6544c71b2 URI |
| 024 | 7 | a https://doi.org/10.1016/j.bbrc.2018.06.1062 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Bartoschek, Michaelu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-mcb |
| 245 | 1 0 | a PDGF family function and prognostic value in tumor biology |
| 264 | 1 | b Elsevier BV,c 2018 |
| 520 | a The development and progression of a tumor depends on the close interaction of malignant cells and the supportive and suppressive tumor microenvironment. Paracrine signaling enables tumor cells to shape the surrounding tissue in order to decrease recognition by the immune system, attract blood vessels to fuel growth, change metabolic programs, and induce wound healing programs. In this study, we investigate the role of the platelet-derived growth factor (PDGF) family members PDGFA, PDGFB, PDGFC and PDGFD and their cognate tyrosine kinase receptors PDGFRA and PDGFRB, using publicly available data from The Cancer Genome Atlas and the Human Protein Atlas. Large scale analysis of expression correlation in RNA sequencing data from 7616 samples derived from 16 tumor types, revealed conserved functional programs in PDGF signaling in the majority of solid tumor types. Besides the well-known effects of PDGF signaling in mesenchymal cells, our analyses revealed a potential role of PDGF signaling in the composition of the immune microenvironment. We furthermore derived gene signatures with increased prognostic value for each PDGF family member. This study emphasizes the potential to impinge on specific paracrine signaling events to interfere with the crosstalk between malignant cells and their microenvironment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a Cancer | |
| 653 | a Expression analysis | |
| 653 | a Platelet-derived growth factor | |
| 700 | 1 | a Pietras, Kristianu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-kpi |
| 710 | 2 | a Avdelningen för translationell cancerforskningb Institutionen för laboratoriemedicin4 org |
| 773 | 0 | t Biochemical and Biophysical Research Communicationsd : Elsevier BVg 503:2, s. 984-990q 503:2<984-990x 0006-291X |
| 856 | 4 | u http://dx.doi.org/10.1016/j.bbrc.2018.06.106x freey FULLTEXT |
| 856 | 4 | u https://doi.org/10.1016/j.bbrc.2018.06.106 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/72b5a96a-b3e6-4e7f-a308-b38a6544c71b |
| 856 | 4 8 | u https://doi.org/10.1016/j.bbrc.2018.06.106 |
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