Association of nut intake with risk factors, cardiovascular disease, and mortality in 16 countries from 5 continents: analysis from the Prospective Urban and Rural Epidemiology (PURE) study

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Fältnamn	Indikatorer	Metadata
000		05103naa a2200817 4500
001		oai:gup.ub.gu.se/295611
003		SwePub
008		240528s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2956112 URI
024	7	a https://doi.org/10.1093/ajcn/nqaa1082 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a de Souza, R. J.4 aut
245	1 0	a Association of nut intake with risk factors, cardiovascular disease, and mortality in 16 countries from 5 continents: analysis from the Prospective Urban and Rural Epidemiology (PURE) study
264	1	b Elsevier BV,c 2020
520		a Background: The association of nuts with cardiovascular disease and deaths has been investigated mostly in Europe, the USA, and East Asia, with few data available from other regions of the world or from low- and middle-income countries. Objective: To assess the association of nuts with mortality and cardiovascular disease (CVD). Methods: The Prospective Urban Rural Epidemiology study is a large multinational prospective cohort study of adults aged 35-70 y from 16 low-, middle-, and high-income countries on 5 continents. Nut intake (tree nuts and ground nuts) was measured at the baseline visit, using country-specific validated FFQs. The primary outcome was a composite of mortality or major cardiovascular event [nonfatal myocardial infarction (MI), stroke, or heart failure]. Results: We followed 124,329 participants (age = 50.7 y, SD= 10.2; 41.5% male) for a median of 9.5 y. We recorded 10,928 composite events [deaths (n = 8,662) or major cardiovascular events (n = 5,979)]. Higher nut intake (>120 g per wk compared with <30 g per mo) was associated with a lower risk of the primary composite outcome of mortality or major cardiovascular event [multivariate HR (mvHR): 0.88; 95% CI: 0.80, 0.96; P-trend = 0.0048]. Significant reductions in total (mvHR: 0.77; 95% CI: 0.69, 0.87; P-trend <0.0001), cardiovascular (mvHR: 0.72; 95% CI: 0.56, 0.92; P-trend = 0.048), and noncardiovascular mortality (mvHR: 0.82; 95% CI: 0.70, 0.96; P-trend = 0.0046) with a trend to reduced cancer mortality (mvHR: 0.81; 95% CI: 0.65, 1.00; P-trend = 0.081) were observed. No significant associations of nuts were seen with major CVD (mvHR: 0.91; 95% CI: 0.81, 1.02; P-trend = 0.14), stroke (mvHR: 0.98; 95% CI: 0.84, 1.14; P-trend = 0.76), or MI (mvHR: 0.86; 95% CI: 0.72, 1.04; P-trend = 0.29). Conclusions: Higher nut intake was associated with lower mortality risk from both cardiovascular and noncardiovascular causes in low-, middle-, and high-income countries.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653		a nuts
653		a mortality
653		a cardiovascular disease
653		a prospective cohort
653		a global
653		a health
653		a coronary-heart-disease
653		a fat dietary pattern
653		a blood-pressure
653		a carbohydrate intake
653		a metabolic syndrome
653		a all-cause
653		a consumption
653		a lipids
653		a metaanalysis
653		a protein
653		a Nutrition & Dietetics
700	1	a Dehghan, M.4 aut
700	1	a Mente, A.4 aut
700	1	a Bangdiwala, S. I.4 aut
700	1	a Ahmed, S. H.4 aut
700	1	a Alhabib, K. F.4 aut
700	1	a Altuntas, Y.4 aut
700	1	a Basiak-Rasala, A.4 aut
700	1	a Dagenais, G. R.4 aut
700	1	a Diaz, R.4 aut
700	1	a Amma, L. I.4 aut
700	1	a Kelishadi, R.4 aut
700	1	a Khatib, R.4 aut
700	1	a Lear, S. A.4 aut
700	1	a Lopez-Jaramillo, P.4 aut
700	1	a Mohan, V.4 aut
700	1	a Poirier, P.4 aut
700	1	a Rangarajan, S.4 aut
700	1	a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xrosan
700	1	a Ismail, R.4 aut
700	1	a Swaminathan, S.4 aut
700	1	a Wentzel-Viljoen, E.4 aut
700	1	a Yeates, K.4 aut
700	1	a Yusuf, R.4 aut
700	1	a Teo, K. K.4 aut
700	1	a Anand, S. S.4 aut
700	1	a Yusuf, S.4 aut
710	2	a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
773	0	t American Journal of Clinical Nutritiond : Elsevier BVg 112:1, s. 208-219q 112:1<208-219x 0002-9165
856	4	u https://academic.oup.com/ajcn/article-pdf/112/1/208/33448131/nqaa108.pdf
856	4 8	u https://gup.ub.gu.se/publication/295611
856	4 8	u https://doi.org/10.1093/ajcn/nqaa108

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