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Sökning: WFRF:(Björnsson H.) > (1995-1999) > Effects of insulin ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003972naa a2200421 4500
001oai:gup.ub.gu.se/49500
003SwePub
008240528s1995 | |||||||||||000 ||eng|
024a https://gup.ub.gu.se/publication/495002 URI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Björnsson, Einar,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xbjoei
2451 0a Effects of insulin and beta-adrenergic blockade on the migrating motor complex in humans
264 1c 1995
520 a BACKGROUND: Interdigestive small-intestinal motility is suppressed by hyperglycemia and also by hyperinsulinemia per se. Since hyperinsulinemia may increase sympathetic activity, the present study was undertaken to ascertain to what extent insulin affects phase III of the migrating motor complex (MMC) and MMC-related duodenal retroperistalsis and whether beta-adrenergic receptors may mediate the effects of insulin. METHODS: Fasting motility was studied in eight healthy volunteers on three occasions with an eight-lumen perfused pressure catheter, with closely spaced recording points in the proximal duodenum. On the control day 5-h antroduodenojejunal manometry was performed. On another study day euglycemic hyperinsulinemic clamping was performed for 2 h after an initial basal recording. On a 3rd day motility was recorded during propranolol infusion, combined with a period of euglycemic hyperinsulinemia. RESULTS: During hyperinsulinemia complete absence of phase III of the MMC in the gastric antrum was observed, whereas 55% of the MMC had a gastric phase-III component on the control day. The duration of phase III in the proximal duodenum was decreased during hyperinsulinemia compared with the control period (p < 0.05). This inhibitory effect of insulin on the activity front was not prevented by beta blockade. Under control conditions the proportion of retroperistaltic pressure waves in the proximal duodenum was 13 +/- 8% in early phase III, increasing in late phase III to 79 +/- 15% (p < 0.01). Duodenal phase III during hyperinsulinemia showed a similar increase in retroperistalsis, from 4 +/- 4% in early phase III to 67 +/- 21% in late phase III (p < 0.01). The corresponding proportions during beta blockade were 16 +/- 10% and 86 +/- 14%, respectively. CONCLUSIONS: Hyperinsulinemia per se abolishes antral phase III and makes the duodenal phase III shorter but does not interrupt the distinct pattern of retroperistalsis in late phase III. Beta-adrenergic receptors seem not to be important for these effects of insulin or for the retroperistalsis in duodenal phase III.
653 a Adult
653 a Duodenum/*physiology
653 a Female
653 a Humans
653 a Insulin/*pharmacology
653 a Male
653 a Myoelectric Complex
653 a Migrating/*drug effects/physiology
653 a Propranolol/*pharmacology
653 a Receptors
653 a Adrenergic
653 a beta/drug effects/*physiology
700a Urbanavicius, V.4 aut
700a Eliasson, Björn,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xelibj
700a Attvall, Stig,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xattst
700a Smith, Ulf,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xsmiul
700a Abrahamsson, H.4 aut
710a Göteborgs universitetb Institutionen för invärtesmedicin4 org
773t Scand J Gastroenterolg 30:3, s. 219-24q 30:3<219-24x 0036-5521
8564 8u https://gup.ub.gu.se/publication/49500

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