WFRF:(Bontkes Hetty J.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05925naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:3bb3d77c-018b-4a4f-8822-2da1212eaf9f | |
| 003 | SwePub | |
| 008 | 171010s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/3bb3d77c-018b-4a4f-8822-2da1212eaf9f2 URI |
| 024 | 7 | a https://doi.org/10.1189/jlb.3MA0117-037R2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb engb swe | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a van Leeuwen-Kerkhoff, Nathalieu Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
| 245 | 1 0 | a Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells |
| 264 | 1 | c 2017 |
| 520 | a Human 6-sulfo LacNac-positive (slan+) cells have been subject to a paradigm debate. They have previously been classified as a distinct dendritic cell (DC) subset. However, evidence has emerged that they may be more related to monocytes than to DCs. To gain deeper insight into the functional specialization of slan+ cells, we have compared them with both conventional myeloid DC subsets (CD1c+ and CD141+) in human peripheral blood (PB). With the use of genome-wide transcriptional profiling, as well as functional tests, we clearly show that slan+ cells form a distinct, non-DC-like population. They cluster away from both DC subsets, and their gene-expression profile evidently suggests involvement in distinct inflammatory processes. An extensive transcriptional meta-analysis confirmed the relationship of slan+ cells with the monocytic compartment rather than with DCs. From a functional perspective, their ability to prime CD4+ and CD8+ T cells is relatively low. Combined with the finding that “antigen presentation by MHC class II” is at the top of under-represented pathways in slan+ cells, this points to a minimal role in directing adaptive T cell immunity. Rather, the higher expression levels of complement receptors on their cell surface, together with their high secretion of IL-1β and IL-6, imply a specific role in innate inflammatory processes, which is consistent with their recent identification as non-classical monocytes. This study extends our knowledge on DC/monocyte subset biology under steady-state conditions and contributes to our understanding of their role in immune-mediated diseases and their potential use in immunotherapeutic strategies. | |
| 520 | a Human 6-sulfo LacNac-positive (slan+) cells have been subject to a paradigm debate. They have previously been classified as a distinct dendritic cell (DC) subset. However, evidence has emerged that they may be more related to monocytes than to DCs. To gain deeper insight into the functional specialization of slan+ cells, we have compared them with both conventional myeloid DC subsets (CD1c+ and CD141+) in human peripheral blood (PB). With the use of genome-wide transcriptional profiling, as well as functional tests, we clearly show that slan+ cells form a distinct, non-DC-like population. They cluster away from both DC subsets, and their gene-expression profile evidently suggests involvement in distinct inflammatory processes. An extensive transcriptional meta-analysis confirmed the relationship of slan+ cells with the monocytic compartment rather than with DCs. From a functional perspective, their ability to prime CD4+ and CD8+ T cells is relatively low. Combined with the finding that “antigen presentation by MHC class II” is at the top of under-represented pathways in slan+ cells, this points to a minimal role in directing adaptive T cell immunity. Rather, the higher expression levels of complement receptors on their cell surface, together with their high secretion of IL-1β and IL-6, imply a specific role in innate inflammatory processes, which is consistent with their recent identification as non-classical monocytes. This study extends our knowledge on DC/monocyte subset biology under steady-state conditions and contributes to our understanding of their role in immune-mediated diseases and their potential use in immunotherapeutic strategies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a Dendritic cell subsets | |
| 653 | a Monocytes | |
| 653 | a Slan | |
| 700 | 1 | a Lundberg, Kristinau Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)medk-klu |
| 700 | 1 | a Westers, Theresia M.u Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut |
| 700 | 1 | a Kordasti, Shahramu King's College Hospital,King's College London4 aut |
| 700 | 1 | a Bontkes, Hetty Ju Academic Centre for Dentistry Amsterdam4 aut |
| 700 | 1 | a Gruijl, Tanja Du Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
| 700 | 1 | a Lindstedt, Malinu Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-mli |
| 700 | 1 | a van de Loosdrecht, Arjan A.u Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut |
| 710 | 2 | a Vrije Universiteit Amsterdamb Amsterdam UMC - Vrije Universiteit Amsterdam4 org |
| 773 | 0 | t Journal of Leukocyte Biologyg 102:4, s. 1055-1068q 102:4<1055-1068x 0741-5400 |
| 856 | 4 | u http://dx.doi.org/10.1189/jlb.3MA0117-037Ry FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3bb3d77c-018b-4a4f-8822-2da1212eaf9f |
| 856 | 4 8 | u https://doi.org/10.1189/jlb.3MA0117-037R |
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