WFRF:(Cardinaud S)
Sökning: WFRF:(Cardinaud S) > Targeting SARS-CoV-...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03455naa a2200697 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:147601739 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1476017392 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-021-25382-02 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Marlin, R4 aut |
| 245 | 1 0 | a Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques |
| 264 | c 2021-09-01 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (αCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. Vaccine-elicited antibodies cross-neutralize different SARS-CoV-2 variants, including D614G, B1.1.7 and to a lesser extent B1.351. Such vaccination significantly improves protection against a new high-dose virulent challenge versus that in non-vaccinated convalescent animals. | |
| 700 | 1 | a Godot, V4 aut |
| 700 | 1 | a Cardinaud, S4 aut |
| 700 | 1 | a Galhaut, M4 aut |
| 700 | 1 | a Coleon, S4 aut |
| 700 | 1 | a Zurawski, S4 aut |
| 700 | 1 | a Dereuddre-Bosquet, N4 aut |
| 700 | 1 | a Cavarelli, M4 aut |
| 700 | 1 | a Gallouet, AS4 aut |
| 700 | 1 | a Maisonnasse, P4 aut |
| 700 | 1 | a Dupaty, L4 aut |
| 700 | 1 | a Fenwick, C4 aut |
| 700 | 1 | a Naninck, T4 aut |
| 700 | 1 | a Lemaitre, J4 aut |
| 700 | 1 | a Gomez-Pacheco, M4 aut |
| 700 | 1 | a Kahlaoui, N4 aut |
| 700 | 1 | a Contreras, V4 aut |
| 700 | 1 | a Relouzat, F4 aut |
| 700 | 1 | a Fang, RHT4 aut |
| 700 | 1 | a Wang, ZQ4 aut |
| 700 | 1 | a Ellis, J4 aut |
| 700 | 1 | a Chapon, C4 aut |
| 700 | 1 | a Centlivre, M4 aut |
| 700 | 1 | a Wiedemann, A4 aut |
| 700 | 1 | a Lacabaratz, C4 aut |
| 700 | 1 | a Surenaud, M4 aut |
| 700 | 1 | a Szurgot, I4 aut |
| 700 | 1 | a Liljestrom, P4 aut |
| 700 | 1 | a Planas, D4 aut |
| 700 | 1 | a Bruel, T4 aut |
| 700 | 1 | a Schwartz, O4 aut |
| 700 | 1 | a van der Werf, S4 aut |
| 700 | 1 | a Pantaleo, G4 aut |
| 700 | 1 | a Prague, M4 aut |
| 700 | 1 | a Thiebaut, R4 aut |
| 700 | 1 | a Zurawski, G4 aut |
| 700 | 1 | a Levy, Y4 aut |
| 700 | 1 | a Le Grand, R4 aut |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 12:1, s. 5215-q 12:1<5215-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-021-25382-0.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147601739 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-021-25382-0 |
Hitta mer i SwePub
- Av författaren/redakt...
- Marlin, R
- Godot, V
- Cardinaud, S
- Galhaut, M
- Coleon, S
- Zurawski, S
- visa fler...
- Dereuddre-Bosque ...
- Cavarelli, M
- Gallouet, AS
- Maisonnasse, P
- Dupaty, L
- Fenwick, C
- Naninck, T
- Lemaitre, J
- Gomez-Pacheco, M
- Kahlaoui, N
- Contreras, V
- Relouzat, F
- Fang, RHT
- Wang, ZQ
- Ellis, J
- Chapon, C
- Centlivre, M
- Wiedemann, A
- Lacabaratz, C
- Surenaud, M
- Szurgot, I
- Liljestrom, P
- Planas, D
- Bruel, T
- Schwartz, O
- van der Werf, S
- Pantaleo, G
- Prague, M
- Thiebaut, R
- Zurawski, G
- Levy, Y
- Le Grand, R
- visa färre...
- Artiklar i publikationen
- Nature communica ...
- Av lärosätet
- Karolinska Institutet
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