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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05058naa a2200769 4500 | |
| 001 | oai:gup.ub.gu.se/310668 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3106682 URI |
| 024 | 7 | a https://doi.org/10.1016/j.eclinm.2021.1010702 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Benjamin, L. A.4 aut |
| 245 | 1 0 | a Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study |
| 264 | 1 | b Elsevier BV,c 2021 |
| 520 | a Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear. Methods: This single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [a beta(2)GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I b2GPI (aD1 beta 2GPI) IgG. Findings: There was a high prevalence of antiphospholipid antibodies in the COVID-neurological (73.3%) and non-neurological COVID-hospitalised controls (76.6%) in contrast to the COVID-non-hospitalised controls (48.2%). aPS/PT IgG titres were significantly higher in the COVID-neurological group compared to both control groups (p < 0.001). Moderate-high titre of aPS/PT IgG was found in 2 out of 3 (67%) patients with acute disseminated encephalomyelitis [ADEM]. aPS/PT IgG titres negatively correlated with oxygen requirement (FiO(2) R=-0.15 p = 0.040) and was associated with venous thromboembolism (p = 0.043). In contrast, aCL IgA (p < 0.001) and IgG (p < 0.001) was associated with non-neurological COVID-hospitalised controls compared to the other groups and correlated positively with D-dimer and creatinine but negatively with FiO(2). Interpretation: Our findings show that aPS/PT IgG is associated with COVID-19-associated ADEM. In contrast, aCL IgA and IgG are seen much more frequently in non-neurological hospitalised patients with COVID-19. Characterisation of antiphospholipid antibody persistence and potential longitudinal clinical impact are required to guide appropriate management. (C) 2021 The Author(s). Published by Elsevier Ltd. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng |
| 653 | a guidelines | |
| 653 | a thrombosis | |
| 653 | a infection | |
| 653 | a update | |
| 653 | a risk | |
| 653 | a General & Internal Medicine | |
| 700 | 1 | a Paterson, R. W.4 aut |
| 700 | 1 | a Moll, R.4 aut |
| 700 | 1 | a Pericleous, C.4 aut |
| 700 | 1 | a Brown, R.4 aut |
| 700 | 1 | a Mehta, P. R.4 aut |
| 700 | 1 | a Athauda, D.4 aut |
| 700 | 1 | a Ziff, O. J.4 aut |
| 700 | 1 | a Heaney, J.4 aut |
| 700 | 1 | a Checkley, A. M.4 aut |
| 700 | 1 | a Houlihan, C. F.4 aut |
| 700 | 1 | a Chou, M.4 aut |
| 700 | 1 | a Heslegrave, A. J.4 aut |
| 700 | 1 | a Chandratheva, A.4 aut |
| 700 | 1 | a Michael, B. D.4 aut |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Vivekanandam, V.4 aut |
| 700 | 1 | a Foulkes, A.4 aut |
| 700 | 1 | a Mummerya, C. J.4 aut |
| 700 | 1 | a Lunn, M. P.4 aut |
| 700 | 1 | a Keddie, S.4 aut |
| 700 | 1 | a Spyer, M. J.4 aut |
| 700 | 1 | a McKinnon, T.4 aut |
| 700 | 1 | a Hart, M.4 aut |
| 700 | 1 | a Carletti, F.4 aut |
| 700 | 1 | a Jager, H. R.4 aut |
| 700 | 1 | a Manji, H.4 aut |
| 700 | 1 | a Zandi, M. S.4 aut |
| 700 | 1 | a Werring, D. J.4 aut |
| 700 | 1 | a Nastoulik, E.4 aut |
| 700 | 1 | a Simister, R.4 aut |
| 700 | 1 | a Solomon, T.4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Schott, J. M.4 aut |
| 700 | 1 | a Cohen, H.4 aut |
| 700 | 1 | a Efthymiou, M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Eclinicalmedicined : Elsevier BVg 39q 39x 2589-5370 |
| 856 | 4 | u http://www.thelancet.com/article/S2589537021003503/pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/310668 |
| 856 | 4 8 | u https://doi.org/10.1016/j.eclinm.2021.101070 |
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- Athauda, D.
- Ziff, O. J.
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- Chandratheva, A.
- Michael, B. D.
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- Vivekanandam, V.
- Foulkes, A.
- Mummerya, C. J.
- Lunn, M. P.
- Keddie, S.
- Spyer, M. J.
- McKinnon, T.
- Hart, M.
- Carletti, F.
- Jager, H. R.
- Manji, H.
- Zandi, M. S.
- Werring, D. J.
- Nastoulik, E.
- Simister, R.
- Solomon, T.
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