Sökning: WFRF:(DeAngelis T.) > (2010-2014) > Array Comparative G...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03408naa a2200409 4500 | |
001 | oai:lup.lub.lu.se:56e47593-546c-4dfe-ba92-2a1ae9c5006c | |
003 | SwePub | |
008 | 160401s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/29949242 URI |
024 | 7 | a https://doi.org/10.1038/jid.2012.1042 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Li, Jian4 aut |
245 | 1 0 | a Array Comparative Genomic Hybridization of Keratoacanthomas and Squamous Cell Carcinomas: Different Patterns of Genetic Aberrations Suggest Two Distinct Entities |
264 | 1 | b Elsevier BV,c 2012 |
520 | a Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with squamous cell carcinomas (SCCs). Furthermore, there are reports of KAs that have metastasized, invoking the question of whether KA is a variant of SCC (Hodak et al., 1993). To date, no reported criteria are sensitive enough to discriminate reliably between KA and SCC, and consequently there is a clinical need for discriminating markers. Our previous study analyzed 132 KAs and 29 SCCs and revealed significantly different regions of genomic aberrations using chromosomal comparative genomic hybridization (CGH). In the present study, we applied array CGH to investigate 98 KAs and 22 SCCs from the above samples. The result shows that all KAs and SCCs have some degree of genetic aberrations. The distribution of numbers of aberrant clones per sample differed significantly between KAs and SCCs (P<0.02), which also demonstrated recurrent aberrations that differed significantly (P<0.001), as illustrated by unsupervised cluster analysis. Classifiers for clinicopathological parameters of KAs were established based on t-test statistics and permutation tests. Tumor size, fibrosis, and inflammation, which are related to the developmental stages of KAs, showed significant (t-test, permutation test) associations with aberrations of selected genomic regions. This suggests chromosomal instability during the whole life cycle of KAs. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng |
700 | 1 | a Wang, Kai4 aut |
700 | 1 | a Gao, Fei4 aut |
700 | 1 | a Jensen, Thomas D.4 aut |
700 | 1 | a Li, Shengting T.4 aut |
700 | 1 | a DeAngelis, Paula M.4 aut |
700 | 1 | a Kolvraa, Steen4 aut |
700 | 1 | a Proby, Charlotte4 aut |
700 | 1 | a Forslund, Olau Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-ofo |
700 | 1 | a Bolund, Lars4 aut |
700 | 1 | a Clausen, Ole Petter F.4 aut |
710 | 2 | a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Journal of Investigative Dermatologyd : Elsevier BVg 132:8, s. 2060-2066q 132:8<2060-2066x 1523-1747x 0022-202X |
856 | 4 | u http://dx.doi.org/10.1038/jid.2012.104y FULLTEXT |
856 | 4 | u http://www.jidonline.org/article/S0022202X1535836X/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/2994924 |
856 | 4 8 | u https://doi.org/10.1038/jid.2012.104 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy