Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients

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Fältnamn	Indikatorer	Metadata
000		04126naa a2200577 4500
001		oai:DiVA.org:umu-176186
003		SwePub
008		201026s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1761862 URI
024	7	a https://doi.org/10.1093/rheumatology/kez5572 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Roelsgaard, Ida K.4 aut
245	1 0	a Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
264		c 2019-11-28
264	1	b Oxford University Press,c 2020
338		a electronic2 rdacarrier
520		a Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
700	1	a Ikdahl, Eirik4 aut
700	1	a Rollefstad, Silvia4 aut
700	1	a Wibetoe, Grunde4 aut
700	1	a Esbensen, Bente A.4 aut
700	1	a Kitas, George D.4 aut
700	1	a van Riel, Piet4 aut
700	1	a Gabriel, Sherine4 aut
700	1	a Kvien, Tore K.4 aut
700	1	a Douglas, Karen4 aut
700	1	a Wållberg-Jonsson, Solveig,d 1953-u Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sowa0001
700	1	a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
700	1	a Karpouzas, George4 aut
700	1	a Dessein, Patrick H.4 aut
700	1	a Tsang, Linda4 aut
700	1	a El-Gabalawy, Hani4 aut
700	1	a Hitchon, Carol A.4 aut
700	1	a Pascual-Ramos, Virginia4 aut
700	1	a Contreras-Yanez, Irazu4 aut
700	1	a Sfikakis, Petros P.4 aut
700	1	a Gonzalez-Gay, Miguel A.4 aut
700	1	a Crowson, Cynthia S.4 aut
700	1	a Semb, Anne Grete4 aut
710	2	a Umeå universitetb Reumatologi4 org
773	0	t Rheumatologyd : Oxford University Pressg 59:8, s. 1997-2004q 59:8<1997-2004x 1462-0324x 1462-0332
856	4	u https://umu.diva-portal.org/smash/get/diva2:1479294/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://doi.org/10.1093/rheumatology/kez557
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176186
856	4 8	u https://doi.org/10.1093/rheumatology/kez557

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