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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009005naa a2200685 4500
001oai:DiVA.org:oru-110604
003SwePub
008240109s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:154524990
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1106042 URI
0247 a https://doi.org/10.3390/jcm122475422 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1545249902 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dey, Mrinaliniu Centre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UK4 aut
2451 0a COVID-19 Vaccination-Related Delayed Adverse Events among Patients with Systemic Lupus Erythematosus
264 1b MDPI,c 2023
338 a print2 rdacarrier
500 a IP is supported by grants from the Swedish Rheumatism Association (R-969696), King Gustaf V's 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckel-fonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet.
520 a BACKGROUND: The safety profile of COVID-19 vaccination is well documented, but hesitancy among people with immune-mediated inflammatory diseases, often immunocompromised, remains high, partially due to a scarcity of data on safety over a longer term. We herein aimed to assess delayed adverse events (DAEs) occurring >7 days after COVID-19 vaccination in systemic lupus erythematosus (SLE) versus other rheumatic autoimmune diseases (rAIDs), non-rheumatic AIDs (nrAIDs), and healthy controls (HCs).METHODS: Self-reported data were captured within the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 online survey, which comprised >150 centres and responses from 106 countries, between February and June 2022. Logistic regression analysis adjusting for important confounders (age, sex, ethnicity) was used to compare groups.RESULTS: Of 7203 eligible individuals, 882 (12.2%) patients had SLE, 3161 (43.9%) patients had rAIDs, 426 (5.9%) patients had nrAIDs, and 2734 (38.0%) were HCs. SLE patients had a median age of 39 years (IQR: 31-50); 93.7% were women. SLE patients reported, more frequently, major DAEs (OR: 1.6; 95% CI: 1.2-2.0; p = 0.001) and hospitalisation (OR: 2.2; 95% CI: 1.4-3.4; p < 0.001) compared to HCs, severe rashes (OR: 2.4; 95% CI: 1.3-4.2; p = 0.004) compared to people with rAIDS, and hospitalisation (OR: 2.3; 95% CI: 1.1-4.9; p = 0.029) as well as several minor DAEs compared to people with nrAIDs. Differences were observed between vaccines in terms of frequency of major DAEs and hospitalisations, with the latter seen more frequently in patients receiving the Moderna vaccine. People with SLE with no autoimmune multimorbidity less frequently reported overall minor DAEs compared to SLE patients with comorbid nrAIDs (OR: 0.5; 95% CI: 0.3-1.0; p = 0.036).CONCLUSION: Hospitalisations post-vaccination were more frequent in SLE patients than in HCs. Monitoring of SLE patients following COVID-19 vaccination can help in identifying DAEs early, informing patients about expected DAEs, and supporting patients, especially those with autoimmune multimorbidity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a COVID-19
653 a delayed adverse events
653 a systemic lupus erythematosus
653 a vaccines
7001 a Doskaliuk, Bohdanau Department of Pathophysiology, Ivano-Frankivsk National Medical University, 76018 Ivano-Frankivsk, Ukraine4 aut
7001 a Lindblom, Juliusu Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a Nikiphorou, Elenau Centre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UK; Rheumatology Department, King's College Hospital, London, UK4 aut
7001 a Wincup, Chrisu Rheumatology Department, King's College Hospital, London, UK4 aut
7001 a Fathima, Madihau Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a Saha, Sreoshyu Mymensingh Medical College, Mymensingh, Bangladesh4 aut
7001 a Shaharir, Syahrul Sazliyanau Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia4 aut
7001 a Katchamart, Wanruchadau Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10100, Thailand4 aut
7001 a Goo, Phonpen Akarawatcharangurau Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand4 aut
7001 a Traboco, Lisau Department of Medicine, Section of Rheumatology, St. Luke's Medical Center-Global City, Taguig, Philippines4 aut
7001 a Chen, Yi-Mingu Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan4 aut
7001 a Kadam, Eshau Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India4 aut
7001 a Lilleker, James B.u Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK4 aut
7001 a Nune, Arvindu Southport and Ormskirk Hospital NHS Trust, Southport, UK4 aut
7001 a Pauling, John D.u Bristol Medical School Translational Health Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, North Bristol NHS Trust, Bristol, UK4 aut
7001 a Agarwal, Vishweshu Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India4 aut
7001 a Dey, Dzifau Rheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Korle-Bu, Accra, Ghana4 aut
7001 a Toro Gutierrez, Carlos Enriqueu Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Cali 760046, Colombia4 aut
7001 a Caballero, Carlo Viniciou Department of Medicine, Hospital Universidad del Norte, Barranquilla, Colombia4 aut
7001 a Chinoy, Hectoru Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK4 aut
7001 a Aggarwal, Rohitu Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, USA4 aut
7001 a Agarwal, Vikasu Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India4 aut
7001 a Gupta, Latikau Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK; Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK4 aut
7001 a Parodis, Ioannis,d 1981-u Örebro universitet,Institutionen för medicinska vetenskaper,Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)isps
7001 a Covad Study Group, -u Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand4 ctb
7102 a Centre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UKb Department of Pathophysiology, Ivano-Frankivsk National Medical University, 76018 Ivano-Frankivsk, Ukraine4 org
7730 t Journal of Clinical Medicined : MDPIg 12:24q 12:24x 2077-0383
8564 u https://doi.org/10.3390/jcm12247542y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110604
8564 8u https://doi.org/10.3390/jcm12247542
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:154524990

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