WFRF:(Dunning Nicholas P.)
Sökning: WFRF:(Dunning Nicholas P.) > (2020-2024) > Brain injury in COV...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06110naa a2200817 4500 | |
| 001 | oai:gup.ub.gu.se/320574 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3205742 URI |
| 024 | 7 | a https://doi.org/10.1093/brain/awac3212 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Needham, E. J.4 aut |
| 245 | 1 0 | a Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses |
| 264 | c 2022-09-06 | |
| 264 | 1 | b Oxford University Press (OUP),c 2022 |
| 520 | a COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19 severity. The true frequency and underlying mechanisms of neurological injury are unknown, but exaggerated host inflammatory responses appear to be a key driver of COVID-19 severity. We investigated the dynamics of, and relationship between, serum markers of brain injury [neurofilament light (NfL), glial fibrillary acidic protein (GFAP) and total tau] and markers of dysregulated host response (autoantibody production and cytokine profiles) in 175 patients admitted with COVID-19 and 45 patients with influenza. During hospitalization, sera from patients with COVID-19 demonstrated elevations of NfL and GFAP in a severity-dependent manner, with evidence of ongoing active brain injury at follow-up 4 months later. These biomarkers were associated with elevations of pro-inflammatory cytokines and the presence of autoantibodies to a large number of different antigens. Autoantibodies were commonly seen against lung surfactant proteins but also brain proteins such as myelin associated glycoprotein. Commensurate findings were seen in the influenza cohort. A distinct process characterized by elevation of serum total tau was seen in patients at follow-up, which appeared to be independent of initial disease severity and was not associated with dysregulated immune responses unlike NfL and GFAP. These results demonstrate that brain injury is a common consequence of both COVID-19 and influenza, and is therefore likely to be a feature of severe viral infection more broadly. The brain injury occurs in the context of dysregulation of both innate and adaptive immune responses, with no single pathogenic mechanism clearly responsible. Needham et al. reveal elevations in blood biomarkers of brain injury in patients hospitalised with COVID-19. The changes, which were severity-dependent, were associated with dysregulated immune responses including increases in pro-inflammatory cytokines and autoantibodies. Ongoing active brain injury could still be seen months after infection. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a COVID-19 | |
| 653 | a brain injury | |
| 653 | a neuroinflammation | |
| 653 | a autoantibodies | |
| 653 | a infection | |
| 653 | a Neurosciences & Neurology | |
| 700 | 1 | a Ren, A. L.4 aut |
| 700 | 1 | a Digby, R. J.4 aut |
| 700 | 1 | a Norton, E. J.4 aut |
| 700 | 1 | a Ebrahimi, S.4 aut |
| 700 | 1 | a Outtrim, J. G.4 aut |
| 700 | 1 | a Chatfield, D. A.4 aut |
| 700 | 1 | a Manktelow, A. E.4 aut |
| 700 | 1 | a Leibowitz, M. M.4 aut |
| 700 | 1 | a Newcombe, V. F. J.4 aut |
| 700 | 1 | a Doffinger, R.4 aut |
| 700 | 1 | a Barcenas-Morales, G.4 aut |
| 700 | 1 | a Fonseca, C.4 aut |
| 700 | 1 | a Taussig, M. J.4 aut |
| 700 | 1 | a Burnstein, R. M.4 aut |
| 700 | 1 | a Samanta, R. J.4 aut |
| 700 | 1 | a Dunai, C.4 aut |
| 700 | 1 | a Sithole, N.4 aut |
| 700 | 1 | a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Gisslén, Magnus,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xgissm |
| 700 | 1 | a Edén, Arvid,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xedear |
| 700 | 1 | a Marklund, Emelieu Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xmaeme |
| 700 | 1 | a Openshaw, P. J. M.4 aut |
| 700 | 1 | a Dunning, J.4 aut |
| 700 | 1 | a Griffiths, M. J.4 aut |
| 700 | 1 | a Cavanagh, J.4 aut |
| 700 | 1 | a Breen, G.4 aut |
| 700 | 1 | a Irani, S. R.4 aut |
| 700 | 1 | a Elmer, A.4 aut |
| 700 | 1 | a Kingston, N.4 aut |
| 700 | 1 | a Summers, C.4 aut |
| 700 | 1 | a Bradley, J. R.4 aut |
| 700 | 1 | a Taams, L. S.4 aut |
| 700 | 1 | a Michael, B. D.4 aut |
| 700 | 1 | a Bullmore, E. T.4 aut |
| 700 | 1 | a Smith, K. G. C.4 aut |
| 700 | 1 | a Lyons, P. A.4 aut |
| 700 | 1 | a Coles, A. J.4 aut |
| 700 | 1 | a Menon, D. K.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Braind : Oxford University Press (OUP)g 145:11, s. 4097-4107q 145:11<4097-4107x 0006-8950x 1460-2156 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/320574 |
| 856 | 4 8 | u https://doi.org/10.1093/brain/awac321 |
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- Fonseca, C.
- Taussig, M. J.
- Burnstein, R. M.
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- Dunai, C.
- Sithole, N.
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- Zetterberg, Henr ...
- Gisslén, Magnus, ...
- Edén, Arvid, 197 ...
- Marklund, Emelie
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- Dunning, J.
- Griffiths, M. J.
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- Breen, G.
- Irani, S. R.
- Elmer, A.
- Kingston, N.
- Summers, C.
- Bradley, J. R.
- Taams, L. S.
- Michael, B. D.
- Bullmore, E. T.
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- Lyons, P. A.
- Coles, A. J.
- Menon, D. K.
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