Planar nanoneedles on-chip for intracellular measurements

• We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60-cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Annan teknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Other Engineering and Technologies (hsv//eng)

Nyckelord

Intracellular

Micro-machining

Nanofluidics

Nanoneedles

Publikations- och innehållstyp

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