WFRF:(Ewenstein B. M.)
Search: WFRF:(Ewenstein B. M.) > (2010-2014) > Factor VIII require...
- 2 of 3
- Previous record
- Next record
- To hitlist
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A : influences of variance in pharmacokinetics and treatment regimens
- Collins, P. W. (author)
-
- Björkman, Sven (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,PKPD
- Fischer, K. (author)
- show more...
- Blanchette, V. (author)
- Oh, M. (author)
- Schroth, P. (author)
- Fritsch, S. (author)
- Casey, K. (author)
- Spotts, G. (author)
- Ewenstein, B. M. (author)
- show less...
- (creator_code:org_t)
- International Society on Thrombosis and Haemostasis, 2010
- 2010
- English.
- In: Journal of Thrombosis and Haemostasis. - : International Society on Thrombosis and Haemostasis. - 1538-7933 .- 1538-7836. ; 8:2, s. 269-275
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BACKGROUND: Prophylactic factor (F)VIII has been shown to reduce bleeds and arthropathy in patients with severe hemophilia A. OBJECTIVES: Assuming that the trough FVIII level is an important determinant of the efficacy of prophylaxis, this paper addresses the effect of the inter-patient variability in pharmacokinetics and different dosing regimens on trough levels. METHODS: Simulations used FVIII half-lives and in vivo recoveries (IVR), observed during clinical trials with Advate [Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method], and commonly used prophylactic regimens to calculate their effect on FVIII levels during prophylaxis. RESULTS AND CONCLUSIONS: Half-life and dose frequency had a larger effect on trough FVIII and time per week with FVIII<1 IU dL(-1) than IVR and infused dose per kg. The combined effect of these parameters resulted in substantial inter-patient variability in the amount of FVIII required to sustain a desired trough level. Prophylactic regimens based on Monday, Wednesday, Friday dosing were less cost effective in maintaining a desired trough level throughout the week. Dose escalation on Friday to cover the weekend would require potentially harmful doses of FVIII in many patients, especially in young children where more than 50% would require a Friday dose of over 100 IU kg(-1) and some would require more than 400 IU kg(-1). Knowledge of individual patients' half-lives and alteration of frequency of infusions may allow the more cost-effective use of FVIII and potentially expand access to prophylaxis to a greater number of patients, especially in regions where healthcare resources are scarce.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- PHARMACY
- FARMACI
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Journal of Thrombosis and Haemostasis (Search for host publication in LIBRIS)
To the university's database
- 2 of 3
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Collins, P. W.
- Björkman, Sven
- Fischer, K.
- Blanchette, V.
- Oh, M.
- Schroth, P.
- show more...
- Fritsch, S.
- Casey, K.
- Spotts, G.
- Ewenstein, B. M.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Pharmaceutical S ...
- Articles in the publication
- Journal of Throm ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
