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Levodopa Dose Equiv...
Levodopa Dose Equivalency in Parkinson's Disease : Updated Systematic Review and Proposals
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- Jost, Stefanie T. (author)
- University Hospital of Cologne
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- Kaldenbach, Marie Ann (author)
- University Hospital of Cologne
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- Antonini, Angelo (author)
- University of Padova
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- Martinez-Martin, Pablo (author)
- CIBER Enfermedades Neurodegenerativas (CIBERNED)
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- Timmermann, Lars (author)
- University Hospital Giessen and Marburg
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- Odin, Per (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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Katzenschlager, Regina (author)
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Borgohain, Rupam (author)
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- Fasano, Alfonso (author)
- University of Toronto,Toronto Western Hospital
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- Stocchi, Fabrizio (author)
- IRCCS San Raffaele Pisana
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Hattori, Nobutaka (author)
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- Kukkle, Prashanth Lingappa (author)
- Manipal Hospital
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- Rodríguez-Violante, Mayela (author)
- Instituto Nacional de Neurología y Neurocirugía
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- Falup-Pecurariu, Cristian (author)
- Transylvania University Brasov
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- Schade, Sebastian (author)
- University Medical Center Göttingen
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- Petry-Schmelzer, Jan Niklas (author)
- University Hospital of Cologne
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- Metta, Vinod (author)
- King's College Hospital,King's College London
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- Weintraub, Daniel (author)
- Veterans Health Administration,University of Pennsylvania
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- Deuschl, Guenther (author)
- University Medical Center Schleswig-Holstein
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- Espay, Alberto J. (author)
- University of Cincinnati
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- Tan, Eng King (author)
- Singapore General Hospital,Duke–NUS Medical School
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Bhidayasiri, Roongroj (author)
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- Fung, Victor S.C. (author)
- Westmead Hospital
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- Cardoso, Francisco (author)
- Federal University of Minas Gerais
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- Trenkwalder, Claudia (author)
- Paracelsus-Elena-Klinik Kassel,University Medical Center Göttingen
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- Jenner, Peter (author)
- King's College London
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- Ray Chaudhuri, K. (author)
- South London and Maudsley NHS Foundation Trust,University Medical Center Göttingen
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- Dafsari, Haidar S. (author)
- University Hospital of Cologne
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(creator_code:org_t)
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- 2023
- 2023
- English.
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In: Movement Disorders. - 0885-3185. ; 38:7, s. 1236-1252
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed. Objectives: To update LED conversion formulae based on a systematic review. Methods: The MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency. Results: The systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon. Conclusions: The LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non-pharmacological interventions in PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- LEDD
- levodopa equivalent daily dose
- levodopa equivalent dose
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Jost, Stefanie T ...
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Kaldenbach, Mari ...
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Antonini, Angelo
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Martinez-Martin, ...
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Timmermann, Lars
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Odin, Per
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Katzenschlager, ...
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Borgohain, Rupam
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Fasano, Alfonso
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Stocchi, Fabrizi ...
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Hattori, Nobutak ...
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Kukkle, Prashant ...
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Rodríguez-Violan ...
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Falup-Pecurariu, ...
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Schade, Sebastia ...
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Petry-Schmelzer, ...
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Metta, Vinod
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Weintraub, Danie ...
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Deuschl, Guenthe ...
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Espay, Alberto J ...
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Tan, Eng King
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Bhidayasiri, Roo ...
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Fung, Victor S.C ...
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Cardoso, Francis ...
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Trenkwalder, Cla ...
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Jenner, Peter
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Ray Chaudhuri, K ...
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Dafsari, Haidar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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Movement Disorde ...
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Lund University