Incidence of Extraarticular Rheumatoid Arthritis in Olmsted County, Minnesota, in 1995-2007 Versus 1985-1994: A Population-based Study.

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Fältnamn	Indikatorer	Metadata
000		03640naa a2200361 4500
001		oai:lup.lub.lu.se:81410ea2-81cf-4e13-8e2d-7902c1782a00
003		SwePub
008		160404s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/19375632 URI
024	7	a https://doi.org/10.3899/jrheum.1011332 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Myasoedova, Elena4 aut
245	1 0	a Incidence of Extraarticular Rheumatoid Arthritis in Olmsted County, Minnesota, in 1995-2007 Versus 1985-1994: A Population-based Study.
264		c 2011-04-01
264	1	b The Journal of Rheumatology,c 2011
520		a OBJECTIVE: To assess incidence and mortality effects of extraarticular rheumatoid arthritis (ExRA) in patients with incident RA in 1995-2007 compared to 1985-1994, in Olmsted County, Minnesota, USA. METHODS: Data on incident ExRA were abstracted from medical records of patients with RA - Olmsted County residents who first met the 1987 American College of Rheumatology criteria for RA between January 1, 1995, and December 31, 2007. Patients were followed until death, migration from Olmsted County, or December 31, 2008. ExRA were classified using the predefined criteria and compared to the corresponding 1985-1994 inception RA cohort (n = 147). RESULTS: The 1995-2007 cohort included 463 patients with RA followed for a mean of 6.3 years; mean age was 55.6 years, 69% were women, 67% were positive for rheumatoid factor (RF). The 10-year cumulative incidence of any ExRA (50.1%) and severe ExRA (6.7%) in the 1995-2007 cohort was similar to the 1985-1994 cohort (46.2% and 9.7%, respectively). The 10-year cumulative incidence of vasculitis, but not other features of ExRA, was significantly lower in the 1995-2007 cohort (0.6%) compared to the 1985-1994 cohort (3.6%). RF positivity, erosions/destructive changes, and use of methotrexate, other disease-modifying antirheumatic drugs and systemic corticosteroids were significantly associated with ExRA in the 1995-2007 cohort. ExRA was associated with mortality risk (HR 2.1, 95% CI 1.2, 3.7) in the 1995-2007 cohort. The decrease in mortality following ExRA in the 1995-2007 cohort versus the 1985-1994 cohort did not reach statistical significance (HR 0.6, 95% CI 0.3, 1.2, p = 0.16). CONCLUSION: ExRA remains a common complication associated with increased mortality in RA. The occurrence of vasculitis appears to be decreasing in recent years.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
700	1	a Crowson, Cynthia S4 aut
700	1	a Turesson, Carlu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ctn
700	1	a Gabriel, Sherine E4 aut
700	1	a Matteson, Eric L4 aut
710	2	a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
773	0	t Journal of Rheumatologyd : The Journal of Rheumatologyg 38, s. 983-989q 38<983-989x 0315-162Xx 1499-2752
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/21459933?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.3899/jrheum.101133y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3193155?pdf=render
856	4 8	u https://lup.lub.lu.se/record/1937563
856	4 8	u https://doi.org/10.3899/jrheum.101133

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Av författaren/redakt...: Myasoedova, Elen ...; Crowson, Cynthia ...; Turesson, Carl; Gabriel, Sherine ...; Matteson, Eric L

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