Interchangeability in Left Ventricular Ejection Fraction Measured by Echocardiography and cardiovascular Magnetic Resonance : Not a Perfect Match in the Real World

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Interchangeability in Left Ventricular Ejection Fraction Measured by Echocardiography and cardiovascular Magnetic Resonance : Not a Perfect Match in the Real World

Clark, Joseph (författare): Newham University Hospital

Ionescu, Adrian (författare)

Chahal, C. Anwar A. (författare): Mayo Clinic Minnesota,Barts Health NHS Trust,Hospital of the University of Pennsylvania

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Bhattacharyya, Sanjeev (författare): Barts Health NHS Trust,Queen Mary University

Lloyd, Guy (författare): Barts Health NHS Trust,Queen Mary University

Galanti, Kristian (författare): University G.d'Annunzio of Chieti-Pescara

Gallina, Sabina (författare): University G.d'Annunzio of Chieti-Pescara

Chong, Jun Hua (författare): Duke–NUS Medical School,National Heart Centre Singapore

Petersen, Steffen E. (författare): Queen Mary University,Barts Health NHS Trust

Ricci, Fabrizio (författare): Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University G.d'Annunzio of Chieti-Pescara

Khanji, Mohammed Y. (författare): Queen Mary University,Barts Health NHS Trust,Newham University Hospital

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Elsevier BV, 2023
2023
Engelska.
Ingår i: Current Problems in Cardiology. - : Elsevier BV. - 0146-2806. ; 48:8

Relaterad länk:: http://dx.doi.org/10... (free); visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Forskningsöversikt (refereegranskat)

Abstract Ämnesord

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Comparisons of transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR) derived left ventricular ejection fraction (LVEF) have been reported in core-lab settings but are limited in the real-world setting. We retrospectively identified outpatients from 4 hospital sites who had clinically indicated quantitative assessment of LVEFTTE and LVEFCMR and evaluated their concordance. In 767 patients (mean age 47.6 years; 67.9% males) the median inter-modality interval was 35 days. There was significant positive correlation between the 2 modalities (r = 0.75; P < 0.001). Median LVEF was 54% (IQR 47%, 60%) for TTE and 59% (IQR 51%, 64%) for CMR, (P < 0.001). Normal LVEFTTE was confirmed by CMR in 90.6% of cases. Of patients with severely impaired LVEFTTE, 42.3% were upwardly reclassified by CMR as less severely impaired. The overall proportion of patients that had their LVEF category confirmed by both imaging modalities was 64.4%; Cohen's Kappa 0.41, indicating fair-to-moderate agreement. Overall, CMR upwardly reclassified 28% of patients using the British Society of Echocardiography LVEF grading, 18.6% using the European Society of Cardiology heart failure classification, and 29.6% using specific reference ranges for each modality. In a multi-site “real-worldˮ clinical setting, there was significant discrepancy between LVEFTTE and LVEFCMR measurement. Only 64.4% had their LVEF category confirmed by both imaging modalities. LVEFTTE was generally lower than LVEFCMR. LVEFCMR upwardly reclassified almost half of patients with severe LV dysfunction by LVEFTTE. Clinicians should consider the inter-modality variation before making therapeutic recommendations, particularly as clinical trial LVEF thresholds have historically been guided by echocardiography.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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Av författaren/redakt...: Clark, Joseph; Ionescu, Adrian; Chahal, C. Anwar ...; Bhattacharyya, S ...; Lloyd, Guy; Galanti, Kristia ...; visa fler...; Gallina, Sabina; Chong, Jun Hua; Petersen, Steffe ...; Ricci, Fabrizio; Khanji, Mohammed ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Lunds universitet

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