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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009431naa a2200901 4500
001oai:DiVA.org:uu-423369
003SwePub
008201028s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:144709787
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4233692 URI
0247 a https://doi.org/10.1016/j.jhep.2020.04.0462 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1447097872 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jackson, Sarah S.u Karolinska Institutet4 aut
2451 0a Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project
264 1b ELSEVIER,c 2020
338 a print2 rdacarrier
520 a Background & Aims: Gallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear. Methods: We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study. Results: During 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR >= 5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only. Conclusion: We observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography. Lay summary: Our findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepatic bile duct cancer and extrahepatic bile duct cancer. We did not see this same association in women from Western countries. Age at menopause was not associated with the risk of any biliary tract cancers. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Reproductive factors
653 a Parity
653 a Biliary tract cancer
653 a Gallbladder cancer
7001 a Adami, Hans-Olovu Karolinska Institutet4 aut
7001 a Andreotti, Gabriellau NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Beane-Freeman, Laura E.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a de Gonzalez, Amy Berringtonu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Buring, Julie E.u Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA USA.4 aut
7001 a Fraser, Gary E.u Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA.4 aut
7001 a Freedman, Neal D.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Gapstur, Susan M.u Amer Canc Soc Inc, Behav & Epidemiol Res Grp, Atlanta, GA USA.4 aut
7001 a Gierach, Gretchenu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut
7001 a Grodstein, Francineu Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.4 aut
7001 a Hartge, Patriciau NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Jenab, Mazdau Int Agcy Res Canc IARC WHO, Sect Nutr & Metab, Lyon, France.4 aut
7001 a Kirsh, Victoriau Ontario Inst Canc Res, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.4 aut
7001 a Knutsen, Synnove F.u Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA.4 aut
7001 a Lan, Qingu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Larsson, Susanna C.u Karolinska Institutet,Uppsala universitet,Ortopedi,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden4 aut0 (Swepub:uu)susla720
7001 a Lee, I-Minu Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA USA.4 aut
7001 a Lee, Mei-Hsuanu Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan.4 aut
7001 a Liao, Linda M.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Milne, Roger L.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut
7001 a Monroe, Kristine R.u Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.4 aut
7001 a Neuhouser, Marian L.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, Seattle, WA 98104 USA.4 aut
7001 a O'Brien, Katie M.u NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.4 aut
7001 a Petrick, Jessica L.u Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.4 aut
7001 a Purdue, Mark P.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Rohan, Thomas E.u Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.4 aut
7001 a Sandin, Svenu Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.4 aut
7001 a Sandler, Dale P.u NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.4 aut
7001 a Sawada, Norieu Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan.4 aut
7001 a Shadyab, Aladdin H.u Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.4 aut
7001 a Simon, Tracey G.u Massachusetts Gen Hosp, Dept Med, Div Gastroenterol, Boston, MA USA.;Massachusetts Gen Hosp & Harvard Med, Clin & Translat Epidemiol Unit, Boston, MA USA.4 aut
7001 a Sinha, Rashmiu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Stolzenberg-Solomon, Rachaelu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Tsugane, Shoichirou Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan.4 aut
7001 a Weiderpass, Elisabeteu Int Agcy Res Canc IARC, Lyon, France.4 aut
7001 a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden4 aut0 (Swepub:uu)alwol516
7001 a Yang, Hwai-, Iu Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan.;Acad Sinica, Genom Res Ctr, Taipei, Taiwan.4 aut
7001 a Zheng, Weiu Vanderbilt Univ, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN USA.;Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN 37235 USA.4 aut
7001 a McGlynn, Katherine A.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Campbell, Peter T.u Amer Canc Soc Inc, Behav & Epidemiol Res Grp, Atlanta, GA USA.4 aut
7001 a Koshiol, Jillu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7102 a Karolinska Institutetb NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 org
7730 t Journal of Hepatologyd : ELSEVIERg 73, s. 863-872q 73<863-872x 0168-8278x 1600-0641
8564 u https://europepmc.org/articles/pmc7901003?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423369
8564 8u https://doi.org/10.1016/j.jhep.2020.04.046
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144709787

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