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Amyloid-PET imaging...
Amyloid-PET imaging predicts functional decline in clinically normal individuals
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- Quenon, Lisa (författare)
- Saint-Luc University Hospital,Catholic University of Louvain
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- Collij, Lyduine E. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Vrije Universiteit Amsterdam,Amsterdam Neuroscience
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- Garcia, David Vállez (författare)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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- Lopes Alves, Isadora (författare)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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- Gérard, Thomas (författare)
- Catholic University of Louvain,Saint-Luc University Hospital
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- Malotaux, Vincent (författare)
- Harvard Medical School,Catholic University of Louvain
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- Huyghe, Lara (författare)
- Catholic University of Louvain
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- Gispert, Juan Domingo (författare)
- CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Hospital del Mar Medical Research Institute,Pompeu Fabra University
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- Jessen, Frank (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital of Cologne
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- Visser, Pieter Jelle (författare)
- Maastricht University,Vrije Universiteit Amsterdam
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- den Braber, Anouk (författare)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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- Ritchie, Craig W. (författare)
- University of Edinburgh
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- Boada, Mercè (författare)
- International University of Catalonia,CIBER Enfermedades Neurodegenerativas (CIBERNED)
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- Marquié, Marta (författare)
- CIBER Enfermedades Neurodegenerativas (CIBERNED),International University of Catalonia
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- Vandenberghe, Rik (författare)
- University Hospitals Leuven
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- Luckett, Emma S. (författare)
- Karolinska Institute
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- Schöll, Michael (författare)
- University of Gothenburg,University College London
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- Frisoni, Giovanni B. (författare)
- Geneva University Hospital,University of Geneva
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- Buckley, Christopher (författare)
- GE Healthcare, UK
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Stephens, Andrew (författare)
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- Altomare, Daniele (författare)
- University of Brescia
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Ford, Lisa (författare)
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Birck, Cindy (författare)
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- Mett, Anja (författare)
- GE Healthcare, UK
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Gismondi, Rossella (författare)
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- Wolz, Robin (författare)
- IXICO Plc
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- Grootoonk, Sylke (författare)
- IXICO Plc
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- Manber, Richard (författare)
- IXICO Plc
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- Shekari, Mahnaz (författare)
- Pompeu Fabra University
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- Lhommel, Renaud (författare)
- Catholic University of Louvain,Saint-Luc University Hospital
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- Dricot, Laurence (författare)
- Catholic University of Louvain
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- Ivanoiu, Adrian (författare)
- Saint-Luc University Hospital,Catholic University of Louvain
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- Farrar, Gill (författare)
- GE Healthcare, UK
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- Barkhof, Frederik (författare)
- Vrije Universiteit Amsterdam,University College London,Amsterdam Neuroscience
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- Hanseeuw, Bernard J. (författare)
- Saint-Luc University Hospital,Catholic University of Louvain
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(creator_code:org_t)
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- 2024
- 2024
- Engelska.
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Ingår i: Alzheimer's Research and Therapy. - 1758-9193. ; 16:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: There is good evidence that elevated amyloid-β (Aβ) positron emission tomography (PET) signal is associated with cognitive decline in clinically normal (CN) individuals. However, it is less well established whether there is an association between the Aβ burden and decline in daily living activities in this population. Moreover, Aβ-PET Centiloids (CL) thresholds that can optimally predict functional decline have not yet been established. Methods: Cross-sectional and longitudinal analyses over a mean three-year timeframe were performed on the European amyloid-PET imaging AMYPAD-PNHS dataset that phenotypes 1260 individuals, including 1032 CN individuals and 228 participants with questionable functional impairment. Amyloid-PET was assessed continuously on the Centiloid (CL) scale and using Aβ groups (CL < 12 = Aβ-, 12 ≤ CL ≤ 50 = Aβ-intermediate/Aβ±, CL > 50 = Aβ+). Functional abilities were longitudinally assessed using the Clinical Dementia Rating (Global-CDR, CDR-SOB) and the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q). The Global-CDR was available for the 1260 participants at baseline, while baseline CDR-SOB and A-IADL-Q scores and longitudinal functional data were available for different subsamples that had similar characteristics to those of the entire sample. Results: Participants included 765 Aβ- (61%, Mdnage = 66.0, IQRage = 61.0–71.0; 59% women), 301 Aβ± (24%; Mdnage = 69.0, IQRage = 64.0–75.0; 53% women) and 194 Aβ+ individuals (15%, Mdnage = 73.0, IQRage = 68.0–78.0; 53% women). Cross-sectionally, CL values were associated with CDR outcomes. Longitudinally, baseline CL values predicted prospective changes in the CDR-SOB (bCL*Time = 0.001/CL/year, 95% CI [0.0005,0.0024], p =.003) and A-IADL-Q (bCL*Time = -0.010/CL/year, 95% CI [-0.016,-0.004], p =.002) scores in initially CN participants. Increased clinical progression (Global-CDR > 0) was mainly observed in Aβ+ CN individuals (HRAβ+ vs Aβ- = 2.55, 95% CI [1.16,5.60], p =.020). Optimal thresholds for predicting decline were found at 41 CL using the CDR-SOB (bAβ+ vs Aβ- = 0.137/year, 95% CI [0.069,0.206], p <.001) and 28 CL using the A-IADL-Q (bAβ+ vs Aβ- = -0.693/year, 95% CI [-1.179,-0.208], p =.005). Conclusions: Amyloid-PET quantification supports the identification of CN individuals at risk of functional decline. Trial registration: The AMYPAD PNHS is registered at www.clinicaltrialsregister.eu with the EudraCT Number: 2018-002277-22.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Amyloid-PET
- Centiloid
- Functional decline
- Instrumental activities of daily living
- Preclinical Alzheimer
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Quenon, Lisa
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Collij, Lyduine ...
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Garcia, David Vá ...
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Lopes Alves, Isa ...
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Gérard, Thomas
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Malotaux, Vincen ...
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visa fler...
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Huyghe, Lara
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Gispert, Juan Do ...
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Jessen, Frank
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Visser, Pieter J ...
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den Braber, Anou ...
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Ritchie, Craig W ...
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Boada, Mercè
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Marquié, Marta
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Vandenberghe, Ri ...
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Luckett, Emma S.
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Schöll, Michael
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Frisoni, Giovann ...
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Buckley, Christo ...
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Stephens, Andrew
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Altomare, Daniel ...
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Ford, Lisa
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Birck, Cindy
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Mett, Anja
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Gismondi, Rossel ...
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Wolz, Robin
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Grootoonk, Sylke
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Manber, Richard
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Shekari, Mahnaz
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Lhommel, Renaud
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Dricot, Laurence
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Ivanoiu, Adrian
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Farrar, Gill
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Barkhof, Frederi ...
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Hanseeuw, Bernar ...
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och Klinisk medicin
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och Neurologi
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Alzheimer's Rese ...
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