Postural orthostatic tachycardia syndrome (POTS) : State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1

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Fältnamn	Indikatorer	Metadata
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001		oai:lup.lub.lu.se:2a43db30-dc2d-4e5e-82f3-fb7b7a9fe0c4
003		SwePub
008		210625s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/2a43db30-dc2d-4e5e-82f3-fb7b7a9fe0c42 URI
024	7	a https://doi.org/10.1016/j.autneu.2021.1028282 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Vernino, Stevenu University of Texas Southwestern Medical Center4 aut
245	1 0	a Postural orthostatic tachycardia syndrome (POTS) : State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1
264	1	b Elsevier BV,c 2021
520		a Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder characterized by orthostatic intolerance with excessive heart rate increase without hypotension during upright posture. Patients often experience a constellation of other typical symptoms including fatigue, exercise intolerance and gastrointestinal distress. A typical patient with POTS is a female of child-bearing age, who often first displays symptoms in adolescence. The onset of POTS may be precipitated by immunological stressors such as a viral infection. A variety of pathophysiologies are involved in the abnormal postural tachycardia response; however, the pathophysiology of the syndrome is incompletely understood and undoubtedly multifaceted. Clinicians and researchers focused on POTS convened at the National Institutes of Health in July 2019 to discuss the current state of understanding of the pathophysiology of POTS and to identify priorities for POTS research. This article, the first of two articles summarizing the information discussed at this meeting, summarizes the current understanding of this disorder and best practices for clinical care. The evaluation of a patient with suspected POTS should seek to establish the diagnosis, identify co-morbid conditions, and exclude conditions that could cause or mimic the syndrome. Once diagnosed, management typically begins with patient education and non-pharmacologic treatment options. Various medications are often used to address specific symptoms, but there are currently no FDA-approved medications for the treatment of POTS, and evidence for many of the medications used to treat POTS is not robust.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a Expert consensus
653		a Pathophysiology
653		a Postural orthostatic tachycardia syndrome
653		a Treatment
653		a Workshop
700	1	a Bourne, Kate M.u University of Calgary4 aut
700	1	a Stiles, Lauren E.u Dysautonomia International,Stony Brook University4 aut
700	1	a Grubb, Blair P.u The University of Toledo Medical Center4 aut
700	1	a Fedorowski, Arturu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-afr
700	1	a Stewart, Julian M.u New York Medical College4 aut
700	1	a Arnold, Amy C.u Pennsylvania State University,Vanderbilt University4 aut
700	1	a Pace, Laura A.u University of Utah4 aut
700	1	a Axelsson, Jonasu Karolinska University Hospital4 aut0 (Swepub:lu)jo0150ax
700	1	a Boris, Jeffrey R.u Jeffrey R Boris MD LLC4 aut
700	1	a Moak, Jeffrey P.u George Washington University4 aut
700	1	a Goodman, Brent P.u Mayo Clinic Scottsdale-Phoenix, Arizona4 aut
700	1	a Chémali, Kamal R.u Sentara Healthcare4 aut
700	1	a Chung, Tae H.u Johns Hopkins University School of Medicine4 aut
700	1	a Goldstein, David S.u National Institutes of Health, United States4 aut
700	1	a Diedrich, Andreu Vanderbilt University4 aut
700	1	a Miglis, Mitchell G.u Stanford University4 aut
700	1	a Cortez, Melissa M.u University of Utah4 aut
700	1	a Miller, Amanda J.u Pennsylvania State University4 aut
700	1	a Freeman, Royu Harvard Medical School,Beth Israel Deaconess Medical Center4 aut
700	1	a Biaggioni, Italou Vanderbilt University4 aut
700	1	a Rowe, Peter C.u Johns Hopkins University4 aut
700	1	a Sheldon, Robert S.u University of Calgary4 aut
700	1	a Shibao, Cyndya A.u Vanderbilt University4 aut
700	1	a Systrom, David M.u Harvard Medical School4 aut
700	1	a Cook, Glen A.u Uniformed Services University of the Health Sciences4 aut
700	1	a Doherty, Taylor A.u University of California, San Diego4 aut
700	1	a Abdallah, Hasan I.u Children's Heart Institute4 aut
700	1	a Darbari, Anilu George Washington University4 aut
700	1	a Raj, Satish R.u University of Calgary4 aut
710	2	a University of Texas Southwestern Medical Centerb University of Calgary4 org
773	0	t Autonomic Neuroscience: Basic and Clinicald : Elsevier BVg 235q 235x 1566-0702
856	4	u http://dx.doi.org/10.1016/j.autneu.2021.102828x freey FULLTEXT
856	4	u http://www.autonomicneuroscience.com/article/S1566070221000588/pdf
856	4 8	u https://lup.lub.lu.se/record/2a43db30-dc2d-4e5e-82f3-fb7b7a9fe0c4
856	4 8	u https://doi.org/10.1016/j.autneu.2021.102828

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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