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Plasma biomarkers o...
Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies
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Hamilton, Calum Alexander (author)
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O'Brien, John (author)
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Heslegrave, Amanda (author)
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Laban, Rhiannon (author)
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Donaghy, Paul (author)
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Durcan, Rory (author)
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Lawley, Sarah (author)
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Barnett, Nicola (author)
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Roberts, Gemma (author)
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Firbank, Michael (author)
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Taylor, John-Paul (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Thomas, Alan (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: PSYCHOLOGICAL MEDICINE. - 0033-2917 .- 1469-8978. ; 53:16, s. 7865-7873
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background. Blood biomarkers of Alzheimer's disease (AD) may allow for the early detection of AD pathology in mild cognitive impairment (MCI) due to AD (MCI-AD) and as a co-pathology in MCI with Lewy bodies (MCI-LB). However not all cases of MCI-LB will feature AD pathology. Disease-general biomarkers of neurodegeneration, such as glial fibrillary acidic protein (GFAP) or neurofilament light (NfL), may therefore provide a useful supplement to AD biomarkers. We aimed to compare the relative utility of plasma A beta 42/40, p-tau181, GFAP and NfL in differentiating MCI-AD and MCI-LB from cognitively healthy older adults, and from one another.Methods. Plasma samples were analysed for 172 participants (31 healthy controls, 48 MCI-AD, 28 possible MCI-LB and 65 probable MCI-LB) at baseline, and a subset (n = 55) who provided repeated samples after >= 1 year. Samples were analysed with a Simoa 4-plex assay for A beta 42, A beta 40, GFAP and NfL, and incorporated previously-collected p-tau181 from this same cohort.Results. Probable MCI-LB had elevated GFAP (p < 0.001) and NfL (p = 0.012) relative to controls, but not significantly lower A beta 42/40 (p = 0.06). GFAP and p-tau181 were higher in MCI-AD than MCI-LB. GFAP discriminated all MCI subgroups, from controls (AUC of 0.75), but no plasma-based marker effectively differentiated MCI-AD from MCI-LB. NfL correlated with disease severity and increased with MCI progression over time (p = 0.011).Conclusion. Markers of AD and astrocytosis/neurodegeneration are elevated in MCI-LB. GFAP offered similar utility to p-tau181 in distinguishing MCI overall, and its subgroups, from healthy controls.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- dementia with Lewy bodies
- mild cognitive impairment
- neurodegeneration
- plasma biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hamilton, Calum ...
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O'Brien, John
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Heslegrave, Aman ...
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Laban, Rhiannon
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Donaghy, Paul
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Durcan, Rory
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show more...
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Lawley, Sarah
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Barnett, Nicola
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Roberts, Gemma
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Firbank, Michael
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Taylor, John-Pau ...
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Zetterberg, Henr ...
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Thomas, Alan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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PSYCHOLOGICAL ME ...
- By the university
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University of Gothenburg