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Association between...
Association between indoor microbiome exposure and sick building syndrome (SBS) in junior high schools of Johor Bahru, Malaysia
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- Fu, Xi (författare)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China.
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- Norbäck, Dan (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Yuan, Qianqian (författare)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Li, Yanling (författare)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Zhu, Xunhua (författare)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Hashim, Jamal Hisham (författare)
- Univ Selangor, Shah Alam, Selangor, Malaysia.
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- Hashim, Zailina (författare)
- Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, Serdang, Selangor, Malaysia.
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- Ali, Faridah (författare)
- Johor State Hlth Dept, Primary Care Unit, Johor Baharu, Malaysia.
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- Hu, Qiansheng (författare)
- Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China.
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- Deng, Yiqun (författare)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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- Sun, Yu (författare)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China;Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China. Arbets- och miljömedicin (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 753
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sick building syndrome (SBS) is a collection of nonspecific syndromes linked with the built environment. The occurrence of SBS is associated with humidity, ventilation, moulds and microbial compounds exposure. However, no study has reported the association between indoor microbiome and SBS. In this study, 308 students were surveyed for SBS symptoms from 21 classrooms of 7 junior high schools from Johor Bahru, Malaysia, and vacuum dust from floor, desks and chairs was collected. High throughput amplicon sequencing (16S rRNA gene and ITS region) and quantitative PCR were conducted to characterize the absolute concentration of bacteria and fungi taxa. In total, 326 bacterial and 255 fungal genera were detected in dust with large compositional variation among classrooms. Also, half of these samples showed low compositional similarity to microbiome data deposited in the public database. The number of observed OTUs in Gammaproteobacteria was positively associated with SBS (p = 0.004). Eight microbial genera were associated with SBS (p < 0.01). Bacterial genera, Rhodomicrobium, Scytonema and Microcoleus, were protectively (negatively) associated with ocular and throat symptoms and tiredness, and Izhakiella and an unclassified genus from Euzebyaceae were positively associated with the throat and ocular symptoms. Three fungal genera, Polychaeton, Gympopus and an unclassified genus from Microbotryaceae, were mainly positively associated with tiredness. The associations differed with our previous study in microbial compounds (endotoxin and ergosterol) and SBS in the same population, in which nasal and dermal symptoms were affected. A higher indoor relative humidity and visible dampness or mould in classrooms were associated with a higher concentration of potential risk bacteria and a lower concentration of potential protective bacteria (p < 0.01). This is the first study to characterize the SBS-associated microorganisms in the indoor environment, revealing complex interactions between microbiome, SBS symptoms and environmental characteristics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Indoor microbiome
- Sick building syndrome
- School
- Malaysia
- Bacteria
- Fungi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Fu, Xi
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Norbäck, Dan
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Yuan, Qianqian
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Li, Yanling
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Zhu, Xunhua
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Hashim, Jamal Hi ...
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visa fler...
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Hashim, Zailina
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Ali, Faridah
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Hu, Qiansheng
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Deng, Yiqun
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Sun, Yu
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Uppsala universitet