Sökning: WFRF:(Heiss B.) > Genetic contributio...
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000 | 09351naa a2202005 4500 | |
001 | oai:DiVA.org:su-115943 | |
003 | SwePub | |
008 | 150408s2015 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-101412 | |
009 | oai:prod.swepub.kib.ki.se:130782778 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1159432 URI |
024 | 7 | a https://doi.org/10.1038/mp.2014.1882 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1014122 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1307827782 URI |
040 | a (SwePub)sud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Davies, G.4 aut |
245 | 1 0 | a Genetic contributions to variation in general cognitive function :b a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) |
264 | c 2015-02-03 | |
264 | 1 | b Springer Science and Business Media LLC,c 2015 |
338 | a print2 rdacarrier | |
500 | a AuthorCount:128; | |
520 | a General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health-and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N = 53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P = 3.93 x 10(-9), MIR2113; rs17522122, P = 2.55 x 10(-8), AKAP6; rs10119, P = 5.67 x 10(-9), APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P = 1x10(-6)). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N = 6617) and the Health and Retirement Study (N = 5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e. = 5%) and 28% (s.e. = 7%), respectively. Using polygenic prediction analysis, similar to 1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N = 5487; P = 1.5 x 10(-17)). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
700 | 1 | a Armstrong, N.4 aut |
700 | 1 | a Bis, J. C.4 aut |
700 | 1 | a Bressler, J.4 aut |
700 | 1 | a Chouraki, V.4 aut |
700 | 1 | a Giddaluru, S.4 aut |
700 | 1 | a Hofer, E.4 aut |
700 | 1 | a Ibrahim-Verbaas, C. A.4 aut |
700 | 1 | a Kirin, M.4 aut |
700 | 1 | a Lahti, J.4 aut |
700 | 1 | a van der Lee, S. J.4 aut |
700 | 1 | a Le Hellard, S.4 aut |
700 | 1 | a Liu, T.4 aut |
700 | 1 | a Marioni, R. E.4 aut |
700 | 1 | a Oldmeadow, C.4 aut |
700 | 1 | a Postmus, I.4 aut |
700 | 1 | a Smith, A. V.4 aut |
700 | 1 | a Smith, J. A.4 aut |
700 | 1 | a Thalamuthu, A.4 aut |
700 | 1 | a Thomson, R.4 aut |
700 | 1 | a Vitart, V.4 aut |
700 | 1 | a Wang, J.4 aut |
700 | 1 | a Yu, L.4 aut |
700 | 1 | a Zgaga, L.4 aut |
700 | 1 | a Zhao, W.4 aut |
700 | 1 | a Boxall, R.4 aut |
700 | 1 | a Harris, S. E.4 aut |
700 | 1 | a Hill, W. D.4 aut |
700 | 1 | a Liewald, D. C.4 aut |
700 | 1 | a Luciano, M.4 aut |
700 | 1 | a Adams, H.4 aut |
700 | 1 | a Ames, D.4 aut |
700 | 1 | a Amin, N.4 aut |
700 | 1 | a Amouyel, P.4 aut |
700 | 1 | a Assareh, A. A.4 aut |
700 | 1 | a Au, R.4 aut |
700 | 1 | a Becker, J. T.4 aut |
700 | 1 | a Beiser, A.4 aut |
700 | 1 | a Berr, C.4 aut |
700 | 1 | a Bertram, L.4 aut |
700 | 1 | a Boerwinkle, E.4 aut |
700 | 1 | a Buckley, B. M.4 aut |
700 | 1 | a Campbell, H.4 aut |
700 | 1 | a Corley, J.4 aut |
700 | 1 | a De Jager, P. L.4 aut |
700 | 1 | a Dufouil, C.4 aut |
700 | 1 | a Eriksson, J. G.4 aut |
700 | 1 | a Espeseth, T.4 aut |
700 | 1 | a Faul, J. D.4 aut |
700 | 1 | a Ford, I.4 aut |
700 | 1 | a Gottesman, R. F.4 aut |
700 | 1 | a Griswold, M. E.4 aut |
700 | 1 | a Gudnason, V.4 aut |
700 | 1 | a Harris, T. B.4 aut |
700 | 1 | a Heiss, G.4 aut |
700 | 1 | a Hofman, A.4 aut |
700 | 1 | a Holliday, E. G.4 aut |
700 | 1 | a Huffman, J.4 aut |
700 | 1 | a Kardia, S. L. R.4 aut |
700 | 1 | a Kochan, N.4 aut |
700 | 1 | a Knopman, D. S.4 aut |
700 | 1 | a Kwok, J. B.4 aut |
700 | 1 | a Lambert, J-C4 aut |
700 | 1 | a Lee, T.4 aut |
700 | 1 | a Li, G.4 aut |
700 | 1 | a Li, S-C4 aut |
700 | 1 | a Loitfelder, M.4 aut |
700 | 1 | a Lopez, O. L.4 aut |
700 | 1 | a Lundervold, A. J.4 aut |
700 | 1 | a Lundquist, Andersu Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)anslst97 |
700 | 1 | a Mather, K. A.4 aut |
700 | 1 | a Mirza, S. S.4 aut |
700 | 1 | a Nyberg, Larsu Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)lany0001 |
700 | 1 | a Oostra, B. A.4 aut |
700 | 1 | a Palotie, A.4 aut |
700 | 1 | a Papenberg, Goranu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Germany4 aut |
700 | 1 | a Pattie, A.4 aut |
700 | 1 | a Petrovic, K.4 aut |
700 | 1 | a Polasek, O.4 aut |
700 | 1 | a Psaty, B. M.4 aut |
700 | 1 | a Redmond, P.4 aut |
700 | 1 | a Reppermund, S.4 aut |
700 | 1 | a Rotter, J. I.4 aut |
700 | 1 | a Schmidt, H.4 aut |
700 | 1 | a Schuur, M.4 aut |
700 | 1 | a Schofield, P. W.4 aut |
700 | 1 | a Scott, R. J.4 aut |
700 | 1 | a Steen, V. M.4 aut |
700 | 1 | a Stott, D. J.4 aut |
700 | 1 | a Van Swieten, J. C.4 aut |
700 | 1 | a Taylor, K. D.4 aut |
700 | 1 | a Trollor, J.4 aut |
700 | 1 | a Trompet, S.4 aut |
700 | 1 | a Uitterlinden, A. G.4 aut |
700 | 1 | a Weinstein, G.4 aut |
700 | 1 | a Widen, E.4 aut |
700 | 1 | a Windham, B. G.4 aut |
700 | 1 | a Jukema, J. W.4 aut |
700 | 1 | a Wright, A. F.4 aut |
700 | 1 | a Wright, M. J.4 aut |
700 | 1 | a Yang, Q.4 aut |
700 | 1 | a Amieva, H.4 aut |
700 | 1 | a Attia, J. R.4 aut |
700 | 1 | a Bennett, D. A.4 aut |
700 | 1 | a Brodaty, H.4 aut |
700 | 1 | a de Craen, A. J. M.4 aut |
700 | 1 | a Hayward, C.4 aut |
700 | 1 | a Ikram, M. A.4 aut |
700 | 1 | a Lindenberger, U.4 aut |
700 | 1 | a Nilsson, Lars-Göranu Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),ARC, Karolinska Institutet, Stockholm4 aut0 (Swepub:umu)lani0012 |
700 | 1 | a Porteous, D. J.4 aut |
700 | 1 | a Raikkonen, K.4 aut |
700 | 1 | a Reinvang, I.4 aut |
700 | 1 | a Rudan, I.4 aut |
700 | 1 | a Sachdev, P. S.4 aut |
700 | 1 | a Schmidt, R.4 aut |
700 | 1 | a Schofield, P. R.4 aut |
700 | 1 | a Srikanth, V.4 aut |
700 | 1 | a Starr, J. M.4 aut |
700 | 1 | a Turner, S. T.4 aut |
700 | 1 | a Weir, D. R.4 aut |
700 | 1 | a Wilson, J. F.4 aut |
700 | 1 | a Van Duijn, C.4 aut |
700 | 1 | a Launer, L.4 aut |
700 | 1 | a Fitzpatrick, A. L.4 aut |
700 | 1 | a Seshadri, S.4 aut |
700 | 1 | a Jr, T. H. Mosley4 aut |
700 | 1 | a Deary, I. J.4 aut |
710 | 2 | a Umeå universitetb Umeå centrum för funktionell hjärnavbildning (UFBI)4 org |
773 | 0 | t Molecular Psychiatryd : Springer Science and Business Media LLCg 20:2, s. 183-192q 20:2<183-192x 1359-4184x 1476-5578 |
856 | 4 | u https://doi.org/10.1038/mp.2014.188y Fulltext |
856 | 4 | u https://www.nature.com/articles/mp2014188.pdf |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:808973/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-115943 |
856 | 4 8 | u https://doi.org/10.1038/mp.2014.188 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101412 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130782778 |
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