Signals and Receptors

Heldin, Carl-HenrikUppsala universitet,Ludwiginstitutet för cancerforskning,Science for Life Laboratory, SciLifeLab (författare)

Communication between cells in a multicellular organism occurs by the production of ligands (proteins, peptides, fatty acids, steroids, gases, and other low-molecular-weight compounds) that are either secreted by cells or presented on their surface, and act on receptors on, or in, other target cells. Such signals control cell growth, migration, survival, and differentiation. Signaling receptors can be single-span plasma membrane receptors associated with tyrosine or serine/threonine kinase activities, proteins with seven transmembrane domains, or intracellular receptors. Ligand-activated receptors convey signals into the cell by activating signaling pathways that ultimately affect cytosolic machineries or nuclear transcriptional programs or by directly translocating to the nucleus to regulate transcription.

Lu, BensonSalk Inst Biol Studies, Gene Express Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA. (författare)
Evans, RonSalk Inst Biol Studies, Gene Express Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA. (författare)
Gutkind, J. SilvioNatl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA. (författare)
Uppsala universitetLudwiginstitutet för cancerforskning (creator_code:org_t)

Ingår i:Cold Spring Harbor Perspectives in Biology: Cold Spring Harbor Laboratory8:41943-0264

Av författaren/redakt...: Heldin, Carl-Hen ...; Lu, Benson; Evans, Ron; Gutkind, J. Silv ...

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.