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Myosin light chain and calcium regulating protein differences in chronic musculoskeletal neck and shoulder pain
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- Hadrevi, Jenny (author)
- Umeå universitet,Idrottsmedicin,Department of Community Medicine and Rehabilitation, Sports Medicine Unit, Umeå University, Umeå, Sweden
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- Turkina, Maria V, 1973- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Carlsson, Anders (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för samhällsmedicin,Smärt och rehabiliteringscentrum,Medicinska fakulteten
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- (creator_code:org_t)
- 2016-06-30
- 2016
- English.
- In: Journal of Integrated Omnics. - : Proteomass Scientific Society. - 2182-0287. ; 6:1, s. 1-8
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Proteomic screening analysis has detected myosin light chain (MLC) as a protein implied to be involved in chronic musculoskeletal neck and shoulder pain. Several analyses of MLC proteins have stated a difference in phosphorylation being the determining factor for protein activation hence altered contrability of the muscle in i.e. senescence. In continuation of a previous publication, this study is an attempt to analyze the different MLC isoforms by mass spectrometry and immune-analyses in myalgic and healthy trapezius muscle. In the present study no differences in phosphorylation level between the corresponding individual proteins were detected using LC-MSMS and immunoblotting; instead we assigned different isoforms of regulatory MLCs. To further elucidate the contrability: calcium (Ca2+) regulatory proteins, sarco(endo)plasmic reticulum Ca2+ ATPase 1 (SERCA-1) and calsequestrine (CSQ) were analyzed by western blot. The analysis revealed a significantly increased abundance of SERCA-1 protein in the myalgic muscle and a significantly increased abundance of CSQ in healthy muscle. Myalgic muscle contraction patterns have in previous studies shown to differ from healthy muscle which may be connected to the Ca2+ availability in the muscle. Here we present the proteomic characterization of differences in Ca2+ regulating proteins and particularly regulatory MLCs in trapezius muscle of women with chronic musculoskeletal neck and shoulder pain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Annan medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Other Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- calcium
- masspektrometry
- phosphorylation
- muscle pain
- myosin light chain
- trapezius
- Biochemistry
- biokemi
- Physiology
- fysiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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