SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Henriksson Emma)
 

Search: WFRF:(Henriksson Emma) > Metabolic Profiling...

Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms

Bränn, Emma, 1988- (author)
Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Obstetrik
Malavaki, Christina (author)
Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas, Patras, Greece
Fransson, Emma, PhD, 1973- (author)
Karolinska Institutet,Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institute, Stockholm, Sweden
show more...
Ioannidi, Maria-Konstantina (author)
Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas, Patras, Greece
Henriksson, Hanna E. (author)
Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
Papadopoulos, Fotios C., 1976- (author)
Uppsala universitet,Cervenka: Psykiatri
Chrousos, George P (author)
University Research Institute of Maternal and Child Health and Precision Medicine, UNESCO Chair on Adolescent Health Care, Medical School, National and Kapodistrian University of Athens, Greece
Klapa, Maria I (author)
Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas, Patras, Greece
Skalkidou, Alkistis, 1977- (author)
Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
show less...
 (creator_code:org_t)
2021-06-25
2021
English.
In: Frontiers in Psychiatry. - : Frontiers Media S.A.. - 1664-0640. ; 12
Related links:
https://doi.org/10.3...
show more...
https://uu.diva-port... (primary) (Raw object)
https://www.frontier...
https://urn.kb.se/re...
https://doi.org/10.3...
http://kipublication...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Background: Postpartum depression (PPD) is a devastating disease requiring improvements in diagnosis and prevention. Blood metabolomics identifies biological markers discriminatory between women with and those without antenatal depressive symptoms. Whether this cutting-edge method can be applied to postpartum depressive symptoms merits further investigation. Methods: As a substudy within the Biology, Affect, Stress, Imagine and Cognition Study, 24 women with PPD symptom (PPDS) assessment at 6 weeks postpartum were included. Controls were selected as having a score of ≤ 6 and PPDS cases as ≥12 on the Edinburgh Postnatal Depression Scale. Blood plasma was collected at 10 weeks postpartum and analyzed with gas chromatography-mass spectrometry metabolomics. Results: Variations of metabolomic profiles within the PPDS samples were identified. One cluster showed altered kidney function, whereas the other, a metabolic syndrome profile, both previously associated with depression. Five metabolites (glycerol, threonine, 2-hydroxybutanoic acid, erythritol, and phenylalanine) showed higher abundance among women with PPDSs, indicating perturbations in the serine/threonine and glycerol lipid metabolism, suggesting oxidative stress conditions. Conclusions: Alterations in certain metabolites were associated with depressive pathophysiology postpartum, whereas diversity in PPDS physiologies was revealed. Hence, plasma metabolic profiling could be considered in diagnosis and pathophysiological investigation of PPD toward providing clues for treatment. Future studies require standardization of various subgroups with respect to symptom onset, lifestyle, and comorbidities.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Keyword

GC-MS metabolic profiling
metabolomics
molecular psychiatry
perinatal depression
postpartum depression
precision medicine
pregnancy

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view