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Sökning: WFRF:(Hesselson Stephanie E) > A Common SCN5A Vari...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004195naa a2200541 4500
001oai:lup.lub.lu.se:c540f12f-4ac0-4046-bea4-10096d97b754
003SwePub
008160401s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/48653092 URI
0247 a https://doi.org/10.1111/jce.124832 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ilkhanoff, Leonard4 aut
2451 0a A Common SCN5A Variant Is Associated with PR Interval and Atrial Fibrillation Among African Americans
264 c 2014-08-25
264 1b Wiley,c 2014
520 a rs7629265 and AF Risk ObjectiveWe examined the association of rs7626962 (S1103Y) or rs7629265, a variant in high linkage disequilibrium with S1103Y (r(2) = 0.87 - 1), with sudden cardiac death (SCD) and atrial fibrillation (AF) among African Americans. BackgroundThe SCN5A missense variant S1103Y has been associated with SCD among African Americans in small case-control studies, but larger population-based studies are needed to validate these findings. The association of this variant with AF has not been fully explored. MethodsUsing genotyping data on over 7,000 African Americans from 5 cohorts (Atherosclerosis Risk in Communities [ARIC], Cleveland Family Study [CFS], Jackson Heart Study [JHS], Multi-Ethnic Study of Atherosclerosis [MESA], Cardiovascular Health Study [CHS]), we examined the association of rs7629265 with electrocardiographic PR, QRS, and QT intervals, and with incident AF and SCD. We examined association of S1103Y (rs7626962) with SCD using a population-based case-control study of SCD Cardiac Arrest Blood Study (CABS). ResultsMeta-analyses across 5 cohorts demonstrated that rs7629265 was significantly associated with PR duration ( = -4.1 milliseconds; P = 2.2x10(-6)), but not significantly associated with QRS or QT intervals. In meta-analyses of prospectively followed ARIC and CHS participants (n = 3,656), rs7629265 was associated with increased AF risk (n = 299 AF cases; HR = 1.74, P = 1.9 x 10(-4)). By contrast, rs7629265 was not significantly associated with SCD risk in ARIC (n = 83 SCD cases; P = 0.30) or CHS (n = 54 SCD cases; P = 0.47). Similarly, S1103Y was not significantly associated with SCD risk in CABS (n = 225 SCD cases; P = 0.29). ConclusionThe common SCN5A variant, rs7629265, is associated with increased AF risk and shorter PR interval among African Americans. In contrast to prior reports, we found no evidence of association of rs7629265 or rs7626962 (S1103Y) with SCD risk in the general population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a atrial fibrillation
653 a electrocardiogram
653 a genetics
653 a PR interval
653 a sudden
653 a death
7001 a Arking, Dan E.4 aut
7001 a Lemaitre, Rozenn N.4 aut
7001 a Alonso, Alvaro4 aut
7001 a Chen, Lin Y.4 aut
7001 a Durda, Peter4 aut
7001 a Hesselson, Stephanie E.4 aut
7001 a Kerr, Kathleen F.4 aut
7001 a Magnani, Jared W.4 aut
7001 a Marcus, Gregory M.4 aut
7001 a Schnabel, Renate B.4 aut
7001 a Smith, Gustavu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-gvs
7001 a Soliman, Elsayed Z.4 aut
7001 a Reiner, Alexander P.4 aut
7001 a Sotoodehnia, Nona4 aut
7102 a Kardiologib Sektion II4 org
7730 t Journal of Cardiovascular Electrophysiologyd : Wileyg 25:11, s. 1150-1157q 25:11<1150-1157x 1540-8167x 1045-3873
8564 u http://dx.doi.org/10.1111/jce.12483y FULLTEXT
8564 u https://europepmc.org/articles/pmc4454499?pdf=render
8564 8u https://lup.lub.lu.se/record/4865309
8564 8u https://doi.org/10.1111/jce.12483

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