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Sökning: WFRF:(Hjärtstam Johan 1962) > The influence of th...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004867naa a2200565 4500
001oai:research.chalmers.se:d10664e0-5dde-4d35-aa9c-6d22024f7141
003SwePub
008171008s2016 | |||||||||||000 ||eng|
009oai:gup.ub.gu.se/241269
009oai:DiVA.org:ri-27607
0247 a https://doi.org/10.1016/j.ijpharm.2016.06.0582 DOI
0247 a https://research.chalmers.se/publication/2412692 URI
0247 a https://gup.ub.gu.se/publication/2412692 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-276072 URI
040 a (SwePub)cthd (SwePub)gud (SwePub)ri
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Andersson, Helene,d 1983u RISE,SP Food and Bioscience,Chalmers University of Technology, Sweden4 aut0 (Swepub:cth)bt03anhe
2451 0a The influence of the molecular weight of the water-soluble polymer on phase-separated films for controlled release
264 1b Elsevier BV,c 2016
520 a Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC) can be used for extended release coatings, where the water-soluble HPC may act as a pore former. The aim was to investigate the effect of the molecular weight of HPC on the microstructure and mass transport in phase-separated freestanding EC/HPC films with 30% w/w HPC. Four different HPC grades were used, with weight averaged molecular weights (Mw) of 30.0 (SSL), 55.0 (SL), 83.5 (L) and 365 (M) kg/mol. Results showed that the phase-separated structure changed from HPC-discontinuous to bicontinuous with increasing Mw of HPC. The film with the lowest Mw HPC (SSL) had unconnected oval-shaped HPC-rich domains, leaked almost no HPC and had the lowest water permeability. The remaining higher Mw films had connected complex-shaped pores, which resulted in higher permeabilities. The highest Mw film (M) had the smallest pores and very slow HPC leakage, which led to a slow increase in permeability. Films with grade L and SL released most of their HPC, yet the permeability of the L film was three times higher due to greater pore connectivity. It was concluded that the phase-separated microstructure, the level of pore percolation and the leakage rate of HPC will be affected by the choice of HPC Mw grade used in the film and this will in turn have strong impact on the film permeability.
650 7a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng
653 a Pellet formulation
653 a Controlled release
653 a Hydroxypropyl cellulose
653 a Phase separation
653 a Molecular weight
653 a Film coating
653 a Ethyl cellulose
653 a Controlled release; Ethyl cellulose; Film coating; Hydroxypropyl cellulose; Molecular weight; Pellet formulation; Phase separation
7001 a Häbel, Henrike,d 1987u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers University of Technology, Sweden4 aut0 (Swepub:gu)xhabhe
7001 a Olsson, Anna,d 1985u Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden4 aut0 (Swepub:cth)annaja
7001 a Sandhagen, Sofieu RISE,SP Food and Bioscience,Chalmers University of Technology, Sweden4 aut
7001 a von Corswant, Christianu AstraZeneca AB,AstraZeneca, Sweden4 aut
7001 a Hjärtstam, Johan,d 1962u AstraZeneca AB,AstraZeneca, Sweden4 aut
7001 a Persson, Michael,d 1956u Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden; AkzoNobel, Sweden4 aut0 (Swepub:cth)micper
7001 a Stading, Mats,d 1962u RISE,Structure Design,Chalmers University of Technology, Sweden4 aut0 (Swepub:ri)matsst@ri.se
7001 a Larsson, Anette,d 1966u Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden4 aut0 (Swepub:cth)anettel
7102 a RISEb SP Food and Bioscience4 org
7730 t International Journal of Pharmaceuticsd : Elsevier BVg 511:1, s. 223-235q 511:1<223-235x 0378-5173x 1873-3476
8564 u http://dx.doi.org/10.1016/j.ijpharm.2016.06.058y FULLTEXT
8564 8u https://doi.org/10.1016/j.ijpharm.2016.06.058
8564 8u https://research.chalmers.se/publication/241269
8564 8u https://gup.ub.gu.se/publication/241269
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-27607

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