WFRF:(Hoglinger G. U.)
Sökning: WFRF:(Hoglinger G. U.) > Piericidin A Aggrav...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04032naa a2200577 4500 | |
| 001 | oai:gup.ub.gu.se/212018 | |
| 003 | SwePub | |
| 008 | 240528s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2120182 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.01135572 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hollerhage, M.4 aut |
| 245 | 1 0 | a Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice |
| 264 | c 2014-12-01 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2014 |
| 520 | a Objective: The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors, isolated from streptomyces spp. with global distribution in marine and agricultural habitats. The aim of this study was to determine whether there is a pathogenic interaction of the environmental toxin piericidin A and the P301S mutation. Methods: Transgenic mice expressing human tau with the P301S-mutation (P301S(+/+)) and wild-type mice at 12 weeks of age were treated subcutaneously with vehicle (N=10 P301S(+/+), N = 7 wild-type) or piericidin A (N = 9 P301S(+/+), N = 9 wild-type mice) at a dose of 0.5 mg/kg/d for a period of 28 days via osmotic minipumps. Tau pathology was measured by stereological counts of cells immunoreative with antibodies against phosphorylated tau (AD2, AT8, AT180, and AT100) and corresponding Western blot analysis. Results: Piericidin A significantly increased the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S(+/+) mice, but only to a variable and mild extent in wild-type mice. Furthermore, piericidin A led to increased levels of pathologically phosphorylated tau only in P301S(+/+) mice. While we observed no apparent cell loss in the frontal cortex, the synaptic density was reduced by piericidin A treatment in P301S(+/+) mice. Discussion: This study shows that exposure to piericidin A aggravates the course of genetically determined tau pathology, providing experimental support for the concept of gene-environment interaction in the etiology of tauopathies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a MITOCHONDRIAL COMPLEX-I | |
| 653 | a PROGRESSIVE SUPRANUCLEAR PALSY | |
| 653 | a ATYPICAL | |
| 653 | a PARKINSONISM | |
| 653 | a FRONTOTEMPORAL DEMENTIA | |
| 653 | a STREPTOMYCES PNEUMONIA | |
| 653 | a SYNAPSE | |
| 653 | a LOSS | |
| 653 | a PROTEIN-TAU | |
| 653 | a MUTATION | |
| 653 | a GUADELOUPE | |
| 653 | a INHIBITOR | |
| 700 | 1 | a Deck, R.4 aut |
| 700 | 1 | a de Andrade, A.4 aut |
| 700 | 1 | a Respondek, G.4 aut |
| 700 | 1 | a Xu, H.4 aut |
| 700 | 1 | a Rosler, T. W.4 aut |
| 700 | 1 | a Salama, M.4 aut |
| 700 | 1 | a Carlsson, Thomas,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology4 aut0 (Swepub:gu)xcatho |
| 700 | 1 | a Yamada, E. S.4 aut |
| 700 | 1 | a El Hak, S. A. G.4 aut |
| 700 | 1 | a Goedert, M.4 aut |
| 700 | 1 | a Oertel, W. H.4 aut |
| 700 | 1 | a Hoglinger, G. U.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi4 org |
| 773 | 0 | t Plos Oned : Public Library of Science (PLoS)g 9:12q 9:12x 1932-6203 |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113557&type=printable |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/212018 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0113557 |
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