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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04718naa a2200673 4500 | |
| 001 | oai:gup.ub.gu.se/279748 | |
| 003 | SwePub | |
| 008 | 240910s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2797482 URI |
| 024 | 7 | a https://doi.org/10.1089/neu.2018.62542 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Posti, J. P.4 aut |
| 245 | 1 0 | a Correlation of Blood Biomarkers and Biomarker Panels with Traumatic Findings on Computed Tomography after Traumatic Brain Injury |
| 264 | 1 | b Mary Ann Liebert Inc,c 2019 |
| 520 | a The aim of the study was to examine the ability of eight protein biomarkers and their combinations in discriminating computed tomography (CT)-negative and CT-positive patients with traumatic brain injury (TBI), utilizing highly sensitive immunoassays in a well-characterized cohort. Blood samples were obtained from 160 patients with acute TBI within 24 h of admission. Levels of beta-amyloid isoforms 1-40 (A beta 40) and 1-42 (A beta 42), glial fibrillary acidic protein (GFAP), heart fatty-acid binding protein (H-FABP), interleukin 10 (IL-10), neurofilament light (NF-L), S100 calcium-binding protein B (S100B), and tau were measured. Patients were divided into CT-negative (n = 65) and CT-positive (n = 95), and analyses were conducted separately for TBIs of all severities (Glasgow Coma Scale [GCS] score 3-15) and mild TBIs (mTBIs; GCS 13-15). NF-L, GFAP, and tau were the best in discriminating CT-negative and CT-positive patients, both in patients with mTBI and with all severities. In patients with all severities, area under the curve of the receiver operating characteristic (AUC) was 0.822, 0.817, and 0.781 for GFAP, NF-L, and tau, respectively. In patients with mTBI, AUC was 0.720, 0.689, and 0.676, for GFAP, tau, and NF-L, respectively. The best panel of three biomarkers for discriminating CT-negative and CT-positive patients in the group of all severities was a combination of GFAP+H-FABP+IL-10, with a sensitivity of 100% and specificity of 38.5%. In patients with mTBI, the best panel of three biomarkers was H-FABP+S100B+tau, with a sensitivity of 100% and specificity of 46.4%. Panels of biomarkers outperform individual biomarkers in separating CT-negative and CT-positive patients. Panels consisted mainly of different biomarkers than those that performed best as an individual biomarker. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a biomarkers | |
| 653 | a computed tomography | |
| 653 | a traumatic brain injury | |
| 653 | a fibrillary acidic protein | |
| 653 | a serum neurofilament light | |
| 653 | a plasma-levels | |
| 653 | a ct | |
| 653 | a s100-beta | |
| 653 | a increases | |
| 653 | a diagnosis | |
| 653 | a s100b | |
| 653 | a tau | |
| 700 | 1 | a Takala, R. S. K.4 aut |
| 700 | 1 | a Lagerstedt, L.4 aut |
| 700 | 1 | a Dickens, A. M.4 aut |
| 700 | 1 | a Hossain, I.4 aut |
| 700 | 1 | a Mohammadian, M.4 aut |
| 700 | 1 | a Ala-Seppala, H.4 aut |
| 700 | 1 | a Frantzen, J.4 aut |
| 700 | 1 | a van Gils, M.4 aut |
| 700 | 1 | a Hutchinson, P. J.4 aut |
| 700 | 1 | a Katila, A. J.4 aut |
| 700 | 1 | a Maanpaa, H. R.4 aut |
| 700 | 1 | a Menon, D. K.4 aut |
| 700 | 1 | a Newcombe, V. F.4 aut |
| 700 | 1 | a Tallus, J.4 aut |
| 700 | 1 | a Hrusovsky, K.4 aut |
| 700 | 1 | a Wilson, D. H.4 aut |
| 700 | 1 | a Gill, J.4 aut |
| 700 | 1 | a Sanchez, J. C.4 aut |
| 700 | 1 | a Tenovuo, O.4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Journal of Neurotraumad : Mary Ann Liebert Incg 36:14, s. 2178-89q 36:14<2178-89x 0897-7151x 1557-9042 |
| 856 | 4 | u https://europepmc.org/articles/pmc6909751?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/279748 |
| 856 | 4 8 | u https://doi.org/10.1089/neu.2018.6254 |
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- Takala, R. S. K.
- Lagerstedt, L.
- Dickens, A. M.
- Hossain, I.
- Mohammadian, M.
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- Ala-Seppala, H.
- Frantzen, J.
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- Menon, D. K.
- Newcombe, V. F.
- Tallus, J.
- Hrusovsky, K.
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