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EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
- Langerak, A. W. (author)
- Groenen, P. J. T. A. (author)
- Brueggemann, M. (author)
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- Beldjord, K. (author)
- Bellan, C. (author)
- Bonello, L. (author)
- Boone, E. (author)
- Carter, G. I. (author)
- Catherwood, M. (author)
- Davi, F. (author)
- Delfau-Larue, M-H (author)
- Diss, T. (author)
- Evans, P. A. S. (author)
- Gameiro, P. (author)
- Garcia Sanz, R. (author)
- Gonzalez, D. (author)
- Grand, D. (author)
- Hummel, M. (author)
- Liu, H. (author)
- Lombardia, L. (author)
- Macintyre, E. A. (author)
- Milner, B. J. (author)
- Montes-Moreno, S. (author)
- Schuuring, E. (author)
- Spaargaren, M. (author)
- Hodges, E. (author)
- van Dongen, J. J. M. (author)
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- (creator_code:org_t)
- 2012-08-24
- 2012
- English.
- In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 26:10, s. 2159-2171
- Research review (peer-reviewed)
Abstract
Subject headings
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- PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines for reliable interpretation and reporting are mandatory. Here, the EuroClonality (BIOMED-2) consortium summarizes important pre- and post-analytical aspects of clonality testing, provides guidelines for interpretation of clonality testing results, and presents a uniform way to report the results of the Ig/TCR assays. Starting from an immunobiological concept, two levels to report Ig/TCR profiles are discerned: the technical description of individual (multiplex) PCR reactions and the overall molecular conclusion for B and T cells. Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management (standardized best-practice) in patients with suspected lymphoproliferations.
Keyword
- immunoglobulin
- T-cell receptor
- clonality
- guideline
- lymphoid malignancies
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- ref (subject category)
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- By the author/editor
- Langerak, A. W.
- Groenen, P. J. T ...
- Brueggemann, M.
- Beldjord, K.
- Bellan, C.
- Bonello, L.
- show more...
- Boone, E.
- Carter, G. I.
- Catherwood, M.
- Davi, F.
- Delfau-Larue, M- ...
- Diss, T.
- Evans, P. A. S.
- Gameiro, P.
- Garcia Sanz, R.
- Gonzalez, D.
- Grand, D.
- Håkansson, Å.
- Hummel, M.
- Liu, H.
- Lombardia, L.
- Macintyre, E. A.
- Milner, B. J.
- Montes-Moreno, S ...
- Schuuring, E.
- Spaargaren, M.
- Hodges, E.
- van Dongen, J. J ...
- show less...
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- Leukemia
- By the university
- Uppsala University
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