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Effect of the NU-AG...
Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults : A Randomized Controlled Trial
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- Marseglia, Anna (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Xu, Weili (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China
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- Fratiglioni, Laura (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
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Fabbri, Cristina (författare)
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Berendsen, Agnes A. M. (författare)
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Bialecka-Debek, Agata (författare)
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Jennings, Amy (författare)
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Gillings, Rachel (författare)
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Meunier, Nathalie (författare)
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Caumon, Elodie (författare)
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Fairweather-Tait, Susan (författare)
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Pietruszka, Barbara (författare)
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De Groot, Lisette C. P. G. M. (författare)
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Santoro, Aurelia (författare)
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Franceschi, Claudio (författare)
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(creator_code:org_t)
- 2018-04-04
- 2018
- Engelska.
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Ingår i: Frontiers in Physiology. - : Frontiers Media SA. - 1664-042X. ; 9
- Relaterad länk:
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
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- Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE's dietary intervention on age related cognitive decline.Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65-79 years, from five European centers. Participants were randomly allocated into two groups: control (n = 638), following a habitual diet; and, intervention (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD total score), and five cognitive domains (perceptual speed, executive function, episodic memory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed effects models.Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) from the intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. However, participants with higher adherence to the NU-AGE diet showed statistically significant improvements in global cognition [beta 0.20 (95%CI 0.004, 0.39), p-value = 0.046] and episodic memory [beta 0.15 (95%Cl 0.02, 0.28), p-value = 0.025] after 1 year, compared to those adults with lower adherence.Discussion: High adherence to the culturally adapted, individually tailored, NU-AGE diet could slow down age-related cognitive decline, helping to prevent cognitive impairment and dementia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- randomized controlled trial
- dietary intervention
- cognitive decline
- multicenter
- neuroprotective
- episodic memory
- healthy diet
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Marseglia, Anna
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Xu, Weili
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Fratiglioni, Lau ...
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Fabbri, Cristina
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Berendsen, Agnes ...
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Bialecka-Debek, ...
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Jennings, Amy
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Gillings, Rachel
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Meunier, Nathali ...
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Caumon, Elodie
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Fairweather-Tait ...
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Pietruszka, Barb ...
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De Groot, Lisett ...
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Santoro, Aurelia
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Franceschi, Clau ...
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visa färre...
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Stockholms universitet
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Karolinska Institutet