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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03945naa a2200409 4500 | |
| 001 | oai:DiVA.org:uu-487234 | |
| 003 | SwePub | |
| 008 | 221114s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4872342 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ijid.2022.08.0202 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Marwa, Karol J.u Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania.4 aut |
| 245 | 1 0 | a Lumefantrine plasma concentrations in uncontrolled conditions among patients treated with artemether-lumefantrine for uncomplicated plasmodium falciparum malaria in Mwanza, Tanzania |
| 264 | 1 | b Elsevier,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Therapeutic efficacy of artemether-lumefantrine is highly dependent on adequate systemic exposure to the partner drug lumefantrine particularly day 7 lumefantrine plasma concentration. There has been contradicting findings on the role of the cut-off values in predicting treatment outcomes among malaria patients in malaria endemic regions. This study assesses the day 3 and 7 lumefantrine plasma concentrations including related determinant factors and their influence on treatment outcomes among treated Tanzanian children and adults in uncontrolled conditions (real life condition).Methods: Data was nested from an efficacy study employing the WHO protocol, 2015 for monitoring antimalarial drug efficacy. Lumefantrine plasma concentration was measured by high performance liquid chromatography with ultraviolet (HPLC-UV).Results: Lumefantrine plasma concentrations below 175ng/ml and 20 0ng/ml on day 3 and 7 did not affect adequate clinical and parasitological response (ACPR) and recurrence of infection ( p = 0.428 and 0.239 respectively). Age and baseline parasitemia were not as-sociated to day 3 median lumefantrine plasma concentrations (p = 0.08 and 0.31 respectively) and day 7 lumefantrine plasma concentrations (p = 0.07 and 0.41 respectively). However, the day 3 and day 7 lumefantrine plasma concentrations were significantly higher in males compared to females ( p = 0.03 and 0.042 respectively).Conclusion: Lumefantrine plasma concentrations below cut-off points (175ng/ml and 20 0ng/ml) on day 3 and 7 did not influence treatment outcomes. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
| 653 | a Lumefantrine | |
| 653 | a day 7 concentration | |
| 653 | a day 3 concentration | |
| 653 | a treatment outcomes and Tanzania | |
| 700 | 1 | a Liwa, Anthony C.u Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania.4 aut |
| 700 | 1 | a Konje, Evelineu Catholic Univ Hlth & Allied Sci, Dept Epidemiol & Biostat, Mwanza, Tanzania.4 aut |
| 700 | 1 | a Mwita, Stanleyu Catholic Univ Hlth & Allied Sci, Sch Pharm, Mwanza, Tanzania.4 aut |
| 700 | 1 | a Kamugisha, Erasmusu Catholic Univ Hlth & Allied Sci, Dept Biochem, Mwanza, Tanzania.4 aut |
| 700 | 1 | a Swedberg, Göteu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)goteswed |
| 710 | 2 | a Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania.b Catholic Univ Hlth & Allied Sci, Dept Epidemiol & Biostat, Mwanza, Tanzania.4 org |
| 773 | 0 | t International Journal of Infectious Diseasesd : Elsevierg 123, s. 192-199q 123<192-199x 1201-9712x 1878-3511 |
| 856 | 4 | u https://doi.org/10.1016/j.ijid.2022.08.020y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1710510/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-487234 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ijid.2022.08.020 |
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