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Methods for the dif...
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Davidov, Eugene1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
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Mary Ann Liebert,2004
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-70888
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70888URI
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https://doi.org/10.1089/omi.2004.8.267DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with complex metabolic regulatory networks. By using precise analytical methods to measure biochemical constituents and their relative abundance in whole plasma of transgenic ApoE*3-Leiden mice and an isogenic wild-type control group, simultaneous snapshots of metabolic and protein states were obtained. Novel data processing and multivariate analysis tools such as Impurity Resolution Software (IMPRESS) and Windows-based linear fit program (WINLIN) were used to compare protein and metabolic profiles in parallel. Canonical correlations of the resulting data show quantitative relationships between heterogeneous components in the TG animals. These results, obtained solely from whole plasma analysis allowed us, in a rapid manner, to corroborate previous findings as well as find new events pertaining to dominant and peripheral events in lipoprotein metabolism of a genetically modified mammalian organism in relation to ApoE3, a key mediator of lipoprotein metabolism.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Clish, Clary B.1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Oresic, Matej,1967-1Beyond Genomics, Inc., Waltham, Massachusetts, USA(Swepub:oru)moc
(författare)
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Meys, Michael1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Stochaj, Wayne1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Snell, Philip1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Lavine, Gary1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Londo, Thomas R.1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Adourian, Aram1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Zhang, Xiang1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Johnston, Mark1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Morel, Nicole1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Marple, Edward W.1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Plasterer, Thomas N.1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Neumann, Eric1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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Verheij, ElwinTNO Pharma, Zeist, The Netherlands
(författare)
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Vogels, Jack T. W. E.TNO Pharma, Zeist, The Netherlands
(författare)
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Havekes, Louis M.TNO Prevention and Health, Gaubius Laboratorium, Leiden, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
(författare)
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van der Greef, Jan1Beyond Genomics, Inc., Waltham, Massachusetts, USA; TNO Pharma, Zeist, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
(författare)
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Naylor, Stephen1Beyond Genomics, Inc., Waltham, Massachusetts, USA
(författare)
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1Beyond Genomics, Inc., Waltham, Massachusetts, USATNO Pharma, Zeist, The Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Omics: Mary Ann Liebert8:4, s. 267-2881536-23101557-8100
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Davidov, Eugene
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Clish, Clary B.
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Oresic, Matej, 1 ...
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Meys, Michael
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Stochaj, Wayne
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Snell, Philip
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visa fler...
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Lavine, Gary
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Londo, Thomas R.
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Adourian, Aram
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Zhang, Xiang
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Johnston, Mark
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Morel, Nicole
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Marple, Edward W ...
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Plasterer, Thoma ...
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Neumann, Eric
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Verheij, Elwin
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Vogels, Jack T. ...
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Havekes, Louis M ...
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van der Greef, J ...
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Naylor, Stephen
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