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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004595naa a2200505 4500
001oai:DiVA.org:oru-70888
003SwePub
008190826s2004 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-708882 URI
0247 a https://doi.org/10.1089/omi.2004.8.2672 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Davidov, Eugeneu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
2451 0a Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model
264 1b Mary Ann Liebert,c 2004
338 a print2 rdacarrier
520 a Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with complex metabolic regulatory networks. By using precise analytical methods to measure biochemical constituents and their relative abundance in whole plasma of transgenic ApoE*3-Leiden mice and an isogenic wild-type control group, simultaneous snapshots of metabolic and protein states were obtained. Novel data processing and multivariate analysis tools such as Impurity Resolution Software (IMPRESS) and Windows-based linear fit program (WINLIN) were used to compare protein and metabolic profiles in parallel. Canonical correlations of the resulting data show quantitative relationships between heterogeneous components in the TG animals. These results, obtained solely from whole plasma analysis allowed us, in a rapid manner, to corroborate previous findings as well as find new events pertaining to dominant and peripheral events in lipoprotein metabolism of a genetically modified mammalian organism in relation to ApoE3, a key mediator of lipoprotein metabolism.
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
7001 a Clish, Clary B.u 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Oresic, Matej,d 1967-u 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut0 (Swepub:oru)moc
7001 a Meys, Michaelu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Stochaj, Wayneu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Snell, Philipu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Lavine, Garyu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Londo, Thomas R.u 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Adourian, Aramu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Zhang, Xiangu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Johnston, Marku 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Morel, Nicoleu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Marple, Edward W.u 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Plasterer, Thomas N.u 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Neumann, Ericu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7001 a Verheij, Elwinu TNO Pharma, Zeist, The Netherlands4 aut
7001 a Vogels, Jack T. W. E.u TNO Pharma, Zeist, The Netherlands4 aut
7001 a Havekes, Louis M.u TNO Prevention and Health, Gaubius Laboratorium, Leiden, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands4 aut
7001 a van der Greef, Janu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA; TNO Pharma, Zeist, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands4 aut
7001 a Naylor, Stephenu 1Beyond Genomics, Inc., Waltham, Massachusetts, USA4 aut
7102 a 1Beyond Genomics, Inc., Waltham, Massachusetts, USAb TNO Pharma, Zeist, The Netherlands4 org
7730 t Omicsd : Mary Ann Liebertg 8:4, s. 267-288q 8:4<267-288x 1536-2310x 1557-8100
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70888
8564 8u https://doi.org/10.1089/omi.2004.8.267

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