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Cerebrospinal fluid...
Cerebrospinal fluid antibodies directed against neuron-associated gangliosides in HIV-1 infection
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- Gisslén, Magnus, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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- Lekman, Annika, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
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- Fredman, Pam, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institutionen för klinisk neurovetenskap, Sektionen för kliniska nervsjukdomar,Institute of Clinical Neurosciences, Section of Experimental Neuroscience,Institute of Clinical Neurosciences, Section of Neurological Diseases
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(creator_code:org_t)
- 2000
- 2000
- Engelska.
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Ingår i: Infection. ; 28:3, s. 143-8
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- BACKGROUND: Loss of synapses and neurons is a common finding in HIV-1 infection. Since the in vivo infection of neurons by HIV-1 is limited, indirect factors are likely to contribute to the pathogenesis. PATIENTS AND METHODS: We have analyzed cerebrospinal fluid (CSF) and serum samples from 25 HIV-1-infected individuals (nine with and 16 without CNS complications) and 19 HIV-negative controls with aseptic meningitis or viral encephalitis, for the presence of antibodies directed against the neuron-associated gangliosides GM1, GD1a and GD1b. RESULTS: Positive antibody titers to > or =1 of the gangliosides were found in 13/25 HIV-1-infected patients in CSF and in 17/25 in serum. Significant correlations were found between the presence and titers of CSF antibodies against GM1, GD1a, and GD1b. Six out of nine patients with, and 3/16 without neurological complications (p < 0.05) had positive CSF titers of > or = 1 of the ganglioside antibodies combined with negative serum titers, indicating intrathecal antibody production. In contrast, only 1/19 controls had detectable anti-ganglioside antibodies in the CSF. CONCLUSION: The results should be interpreted with caution and CSF anti-ganglioside antibody production might be a part of a non-specific intrathecal polyclonal immunoactivation. Nevertheless, autoantibodies directed against neuron-associated gangliosides might be involved in the neuropathogenesis in HIV-1 disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Adult
- Antibodies/blood/*cerebrospinal fluid
- Autoantibodies/blood/cerebrospinal fluid
- Encephalitis
- Viral/*cerebrospinal fluid/etiology
- Enzyme-Linked Immunosorbent Assay
- Female
- G(M1) Ganglioside/immunology
- Gangliosides/*immunology
- HIV Infections/blood/*cerebrospinal fluid/complications
- *Hiv-1
- Humans
- Immunoglobulin G/blood/cerebrospinal fluid
- Immunoglobulin M/blood/cerebrospinal fluid
- Lactones/immunology
- Male
- Middle Aged
- Neurons/chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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