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Association between...
Association between sleep duration and metabolic syndrome : linear and nonlinear Mendelian randomization analyses
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- Liang, Yannis Yan (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, 102 Zhongshan Rd, Guangzhou, Guangdong, Peoples R China
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- Chen, Jie (författare)
- Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit,Shatin, Hong Kong, Peoples R China
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- Peng, Miaoguan (författare)
- Guangzhou Med Univ, Affiliated Hosp 3, Dept Endocrinol, Guangzhou, Guangdong, Peoples R China
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- Zhou, Jiajin (författare)
- Kunming Univ Sci & Technol, Affiliated Hosp, Peoples Hosp Yunnan Prov 1, Kunming, Yunnan, Peoples R China
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- Chen, Xinru (författare)
- Southern Med Univ, Sch Clin Med 1, Guangzhou, Peoples R China
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- Tan, Xiao (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Zhejiang Univ, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Peoples R China.;Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou, Peoples R China
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- Wang, Ningjian (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai, Peoples R China
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- Ma, Huan (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou, Guangdong, Peoples R China
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- Guo, Lan (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou, Guangdong, Peoples R China
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- Zhang, Jihui (författare)
- Guangzhou Med Univ, Affiliated Brain Hosp, Ctr Sleep & Circadian Med, 36 Mingxin Rd, Guangzhou, Guangdong, Peoples R China
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- Wing, Yun-Kwok (författare)
- Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit,Shatin, Hong Kong, Peoples R China
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- Geng, Qingshan (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, 102 Zhongshan Rd, Guangzhou, Guangdong, Peoples R China.;Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Geriatr, Shenzhen, Guangdong, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Geriatr, Shenzhen, Guangdong, Peoples R China
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- Ai, Sizhi (författare)
- Guangzhou Med Univ, Affiliated Brain Hosp, Ctr Sleep & Circadian Med, 36 Mingxin Rd, Guangzhou, Guangdong, Peoples R China.;Xinxiang Med Univ, Affiliated Hosp 1, Life Sci Ctr, Dept Cardiol,Heart Ctr, Weihui, Henan, Peoples R China
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(creator_code:org_t)
- 2023-02-07
- 2023
- Engelska.
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Ingår i: Journal of Translational Medicine. - : BioMed Central (BMC). - 1479-5876. ; 21:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Observational studies have found that both short and long sleep duration are associated with increased risk of metabolic syndrome (MetS). This study aimed to examine the associations of genetically determined sleep durations with MetS and its five components (i.e., central obesity, high blood pressure, dyslipidemia, hypertriglyceridemia, and hyperglycemia) among a group of elderly population.Methods In 335,727 participants of White British from the UK Biobank, linear Mendelian randomization (MR) methods were first employed to examine the causal association of genetically predicted continuous sleep duration with MetS and its each component. Nonlinear MR analyses were performed to determine the nonlinearity of these associations. The causal associations of short and long sleep duration with MetS and its components were further assessed by using genetic variants that associated with short (<= 6 h) and long sleep (>= 9 h) durations.Results Linear MR analyses demonstrated that genetically predicted 1-h longer sleep duration was associated with a 13% lower risk of MetS, a 30% lower risk of central obesity, and a 26% lower risk of hyperglycemia. Non-linear MR analyses provided evidence for non-linear associations of genetically predicted sleep duration with MetS and its five components (all P values < 0.008). Genetically predicted short sleep duration was moderately associated with MetS and its four components, including central obesity, dyslipidemia, hypertriglyceridemia, and hyperglycemia (all P values < 0.002), whereas genetically long sleep duration was not associated with MetS and any of its components.Conclusions Genetically predicted short sleep duration, but not genetically predicted long sleep duration, is a potentially causal risk factor for MetS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Mendelian randomization
- Sleep duration
- Metabolic syndrome
- Hyperglycemia
- Obesity
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- art (ämneskategori)
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Liang, Yannis Ya ...
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Chen, Jie
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Peng, Miaoguan
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Zhou, Jiajin
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Chen, Xinru
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Tan, Xiao
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visa fler...
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Wang, Ningjian
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Ma, Huan
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Guo, Lan
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Zhang, Jihui
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Wing, Yun-Kwok
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Geng, Qingshan
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Ai, Sizhi
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Uppsala universitet
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Karolinska Institutet