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WFRF:(Liao Junlin)
 

Sökning: WFRF:(Liao Junlin) > Neurobehavioral cha...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006888naa a2200481 4500
001oai:DiVA.org:oru-79069
003SwePub
008200117s2015 | |||||||||||000 ||eng|
009oai:DiVA.org:kau-41647
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-790692 URI
0247 a https://doi.org/10.1039/c4tx00250d2 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-416472 URI
040 a (SwePub)orud (SwePub)kau
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tang, Jiaqiu Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University , Wuhan, China,Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan, Peoples R China.4 aut
2451 0a Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming mice
264 c 2015
264 1b Royal Society of Chemistry,c 2015
338 a print2 rdacarrier
500 a This work was funded by the Key Project of International Cooperation of the Chinese Ministry of Science and Technology (2010DFA31790) and the Key Project of the National Natural Science Foundation of China (51136002).
520 a Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in PVC that may leach into the environment, and has been shown to adversely affect the health of humans and animals. We undertook a study to ascertain the neurotoxicity of DEHP in Kunming mice. This study included three rounds of testing. In the first round, Kunming mice were exposed to different concentrations of DEHP (0, 5, 50, 500 mg kg(-1) per day) after which their cognitive ability was assessed using the Morris water maze (MWM) test. The reactive oxygen species (ROS) content in tissue and the malondialdehyde (MDA) content of brains were also measured. In the second round, vitamin E (50 mg kg(-1) per day) was given daily as an anti-oxidant via the intragastric route. Cognitive deficits and locomotor activity, as well as ROS and MDA contents were tested employing the same methods. In the third round, the depressive mood of mice after DEHP exposure (500 mg kg(-1) per day) was measured using the open field test, the tail suspension test, and the forced swim test. The main findings of this study include: (1) a statistical association exists between DEHP oral exposure and spatial learning (DEHP 500 mg kg(-1) per day) and memory (DEHP 50 mg kg(-1) per day) dysfunction as ascertained by an MWM test of Kunming mice. (2) A statistical association was also found between DEHP oral exposure (50 and 500 mg kg(-1) per day) and oxidative stress (ROS and MDA) of mouse brain tissue. (3) Co-administration of vitamin E (50 mg kg(-1) per day) diminishes the elevation of ROS and MDA induced by DEHP (50 mg kg(-1) per day) from significant levels to non-significant levels. (4) Co-administration of vitamin E (50 mg kg(-1) per day) protects against mouse memory dysfunction induced by DEHP (50 mg kg(-1) per day) from being significant to being not significant. (5) In the 5 mg kg(-1) per day DEHP exposure groups, oxidative stress in brain tissue, and neurobehavioral changes were not found. (6) High dose DEHP exposure (500 mg kg(-1) per day) may induce behavioral despair in mice. Conclusions: These data suggest that DEHP is neurotoxic with regard to cognitive ability and locomotor activity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Public Health Science
653 a Folkhälsovetenskap
7001 a Yuan, Yeu Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University , Wuhan, China,Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan, Peoples R China.4 aut
7001 a Wei, Chenxiu Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University , Wuhan, China,Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan, Peoples R China.4 aut
7001 a Liao, Xiaomeiu Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University , Wuhan, China,Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan, Peoples R China.4 aut
7001 a Yuan, Junlinu Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University , Wuhan, China,Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan, Peoples R China.4 aut
7001 a Nånberg, Eewa,d 1957-u Department of Health Sciences, Karlstad University, Karlstad, Sweden4 aut0 (Swepub:kau)eewanan
7001 a Zhang, Yinpingu Department of Building Science, Tsinghua University , Beijing, China,Tsinghua Univ, Dept Bldg Sci, Beijing 100084, Peoples R China.4 aut
7001 a Bornehag, Carl-Gustaf,d 1957-u Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)4 aut0 (Swepub:kau)caguborn
7001 a Yang, Xuu Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University , Wuhan, China,Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan, Peoples R China.4 aut
7102 a Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University , Wuhan, Chinab Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan, Peoples R China.4 org
7730 t Toxicology Researchd : Royal Society of Chemistryg 4:4, s. 1006-1015q 4:4<1006-1015x 2045-452Xx 2045-4538
8564 u https://doi.org/10.1039/c4tx00250dy Fulltext
8564 u https://academic.oup.com/toxres/article-pdf/4/4/1006/30225106/c4tx00250d.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79069
8564 8u https://doi.org/10.1039/c4tx00250d
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-41647

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