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A luminal unfolding microneedle injector for oral delivery of macromolecules

Abramson, Alex (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Caffarel-Salvador, Ester (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Soares, Vance (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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Minahan, Daniel (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Tian, Ryan Yu (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Lu, Xiaoya (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Dellal, David (författare)
MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Gao, Yuan (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Kim, Soyoung (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Wainer, Jacob (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Collins, Joy (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Tamang, Siddartha (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Hayward, Alison (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Div Comparat Med, Cambridge, MA 02139 USA.
Yoshitake, Tadayuki (författare)
MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.;MIT, Elect Res Lab, Cambridge, MA 02139 USA.
Lee, Hsiang-Chieh (författare)
MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.;MIT, Elect Res Lab, Cambridge, MA 02139 USA.
Fujimoto, James (författare)
MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.;MIT, Elect Res Lab, Cambridge, MA 02139 USA.
Fels, Johannes (författare)
Global Drug Discovery, Global Res Technol, Malov, Denmark.;Novo Nordisk, Device R&D, Malov, Denmark.
Frederiksen, Morten Revsgaard (författare)
Global Drug Discovery, Global Res Technol, Malov, Denmark.;Novo Nordisk, Device R&D, Malov, Denmark.
Rahbek, Ulrik (författare)
Global Drug Discovery, Global Res Technol, Malov, Denmark.;Novo Nordisk, Device R&D, Malov, Denmark.
Roxhed, Niclas (författare)
KTH,Mikro- och nanosystemteknik,MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
Langer, Robert (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, Cambridge, MA 02139 USA.;MIT, Media Lab, Cambridge, MA 02139 USA.
Traverso, Giovanni (författare)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, Cambridge, MA 02139 USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA.
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MIT, Dept Chem Engn, Cambridge, MA 02139 USA;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA. MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA. (creator_code:org_t)
2019-10-07
2019
Engelska.
Ingår i: Nature Medicine. - : NATURE PUBLISHING GROUP. - 1078-8956 .- 1546-170X. ; 25:10, s. 1512-
Relaterad länk:
https://dspace.mit.e...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Insulin and other injectable biologic drugs have transformed the treatment of patients suffering from diabetes(1,2), yet patients and healthcare providers often prefer to use and prescribe less effective orally dosed medications(3-5). Compared with subcutaneously administered drugs, oral formulations create less patient discomfort(4), show greater chemical stability at high temperatures(6), and do not generate biohazardous needle waste(7). An oral dosage form for biologic medications is ideal; however, macromolecule drugs are not readily absorbed into the bloodstream through the gastrointestinal tract(8). We developed an ingestible capsule, termed the luminal unfolding microneedle injector, which allows for the oral delivery of biologic drugs by rapidly propelling dissolvable drug-loaded microneedles into intestinal tissue using a set of unfolding arms. During ex vivo human and in vivo swine studies, the device consistently delivered the microneedles to the tissue without causing complete thickness perforations. Using insulin as a model drug, we showed that, when actuated, the luminal unfolding microneedle injector provided a faster pharmacokinetic uptake profile and a systemic uptake > 10% of that of a subcutaneous injection over a 4-h sampling period. With the ability to load a multitude of microneedle formulations, the device can serve as a platform to orally deliver therapeutic doses of macromolecule drugs.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

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